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CD14 CD14 molecule [ Homo sapiens (human) ]

Gene ID: 929, updated on 9-Oct-2021

Summary

Official Symbol
CD14provided by HGNC
Official Full Name
CD14 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1628
See related
Ensembl:ENSG00000170458 MIM:158120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Expression
Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues See more
Orthologs
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Genomic context

See CD14 in Genome Data Viewer
Location:
5q31.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (140631732..140633701, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140011317..140013286, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267855 Neighboring gene HAUS augmin like complex subunit 1 pseudogene 1 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene ribosomal protein L36 pseudogene 11 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene microRNA 3655 Neighboring gene IK cytokine

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef CD14 is significantly downregulated from the surface of HIV-1 Nef-expressing THP-1 monocytes compared to that from the surface of control cells PubMed
nef HIV-1 Nef enhances membrane-bound (m) CD14 expression on monocytes but does not induce the release of soluble CD14 into the culture supernatants of PBMC; the upregulation of mCD14 expression does not involve endogenously produced IL-10 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables opsonin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables peptidoglycan immune receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to triacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interferon-gamma production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
monocyte differentiation antigen CD14
Names
myeloid cell-specific leucine-rich glycoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023178.1 RefSeqGene

    Range
    5527..6970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000591.4NP_000582.1  monocyte differentiation antigen CD14 precursor

    See identical proteins and their annotated locations for NP_000582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC010507, CF593452
    Consensus CDS
    CCDS4232.1
    UniProtKB/Swiss-Prot
    P08571
    Related
    ENSP00000304236.6, ENST00000302014.11
    Conserved Domains (2) summary
    COG4886
    Location:167332
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:196223
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_001040021.3NP_001035110.1  monocyte differentiation antigen CD14 precursor

    See identical proteins and their annotated locations for NP_001035110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC010507, DA426297
    Consensus CDS
    CCDS4232.1
    UniProtKB/Swiss-Prot
    P08571
    Conserved Domains (2) summary
    COG4886
    Location:167332
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:196223
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001174104.2NP_001167575.1  monocyte differentiation antigen CD14 precursor

    See identical proteins and their annotated locations for NP_001167575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC010507, BP300412, DA426297
    Consensus CDS
    CCDS4232.1
    UniProtKB/Swiss-Prot
    P08571
    Related
    ENSP00000385519.2, ENST00000401743.6
    Conserved Domains (2) summary
    COG4886
    Location:167332
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:196223
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_001174105.2NP_001167576.1  monocyte differentiation antigen CD14 precursor

    See identical proteins and their annotated locations for NP_001167576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC010507, DA269805, DA426297
    Consensus CDS
    CCDS4232.1
    UniProtKB/Swiss-Prot
    P08571
    Conserved Domains (2) summary
    COG4886
    Location:167332
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:196223
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    140631732..140633701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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