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IMP4 IMP U3 small nucleolar ribonucleoprotein 4 [ Homo sapiens (human) ]

Gene ID: 92856, updated on 7-Jun-2020

Summary

Official Symbol
IMP4provided by HGNC
Official Full Name
IMP U3 small nucleolar ribonucleoprotein 4provided by HGNC
Primary source
HGNC:HGNC:30856
See related
Ensembl:ENSG00000136718 MIM:612981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BXDC4
Summary
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See IMP4 in Genome Data Viewer
Location:
2q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (130342242..130347967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131100470..131104197)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tektin 4 pseudogene 3 Neighboring gene tRNA-Glu (anticodon TTC) 1-1 Neighboring gene coiled-coil domain containing 115 Neighboring gene protein tyrosine phosphatase non-receptor type 18 Neighboring gene uncharacterized LOC105373618

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC19606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Mpp10 complex IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
preribosome IDA
Inferred from Direct Assay
more info
PubMed 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP4
Names
IMP4 homolog, U3 small nucleolar ribonucleoprotein
IMP4, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 4 homolog
U3 snoRNP protein IMP4
brix domain-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320304.2NP_001307233.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    smart00879
    Location:84251
    Brix; The Brix domain is found in a number of eukaryotic proteins
  2. NM_001320305.2NP_001307234.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    smart00879
    Location:84235
    Brix; The Brix domain is found in a number of eukaryotic proteins
  3. NM_001320306.2NP_001307235.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    UniProtKB/TrEMBL
    E7ENR5
    Related
    ENSP00000409371.1, ENST00000452955.1
    Conserved Domains (1) summary
    smart00879
    Location:31198
    Brix; The Brix domain is found in a number of eukaryotic proteins
  4. NM_001320307.2NP_001307236.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    UniProtKB/TrEMBL
    E7ENR5
    Related
    ENSP00000389701.1, ENST00000428740.5
    Conserved Domains (1) summary
    smart00879
    Location:31198
    Brix; The Brix domain is found in a number of eukaryotic proteins
  5. NM_001320309.2NP_001307238.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    Related
    ENST00000460766.5
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  6. NM_001320310.2NP_001307239.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    Related
    ENSP00000386716.1, ENST00000409649.5
    Conserved Domains (1) summary
    smart00879
    Location:1168
    Brix; The Brix domain is found in a number of eukaryotic proteins
  7. NM_001320311.2NP_001307240.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    smart00879
    Location:1165
    Brix; The Brix domain is found in a number of eukaryotic proteins
  8. NM_001371725.1NP_001358654.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC132479
  9. NM_001371726.1NP_001358655.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC132479
  10. NM_001371728.1NP_001358657.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC132479
  11. NM_001371730.1NP_001358659.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC132479
  12. NM_001371731.1NP_001358660.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
  13. NM_001371732.1NP_001358661.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
  14. NM_001371733.1NP_001358662.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
  15. NM_001371734.1NP_001358663.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
  16. NM_033416.3NP_219484.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

    See identical proteins and their annotated locations for NP_219484.1

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Consensus CDS
    CCDS2160.1
    UniProtKB/Swiss-Prot
    Q96G21
    Related
    ENSP00000259239.3, ENST00000259239.8
    Conserved Domains (1) summary
    smart00879
    Location:86253
    Brix; The Brix domain is found in a number of eukaryotic proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    130342242..130347967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453220.1XP_024308988.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform X2

    Conserved Domains (1) summary
    smart00879
    Location:30225
    Brix; The Brix domain is found in a number of eukaryotic proteins
  2. XM_024453221.1XP_024308989.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform X3

    Conserved Domains (1) summary
    smart00879
    Location:30197
    Brix; The Brix domain is found in a number of eukaryotic proteins
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