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IMP4 IMP U3 small nucleolar ribonucleoprotein 4 [ Homo sapiens (human) ]

Gene ID: 92856, updated on 3-May-2025
Official Symbol
IMP4provided by HGNC
Official Full Name
IMP U3 small nucleolar ribonucleoprotein 4provided by HGNC
Primary source
HGNC:HGNC:30856
See related
Ensembl:ENSG00000136718 MIM:612981; AllianceGenome:HGNC:30856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BXDC4
Summary
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues See more
Orthologs
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See IMP4 in Genome Data Viewer
Location:
2q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130342897..130347967)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130776821..130781891)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131100470..131105540)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (anticodon TTC) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16527 Neighboring gene vacuolar ATPase assembly factor VMA22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11957 Neighboring gene protein tyrosine phosphatase non-receptor type 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131129403-131130030 Neighboring gene uncharacterized LOC105373618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11960

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Components of U3 snoRNA-containing complexes shuttle between nuclei and the cytoplasm and differentially localize in nucleoli: implications for assembly and function. Leary DJ, et al. Mol Biol Cell, 2004 Jan. PMID 14565981, Free PMC Article
  2. DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4. Liu C, et al. Thorac Cancer, 2021 Jun. PMID 33973712, Free PMC Article
  3. The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes. Granneman S, et al. Nucleic Acids Res, 2003 Apr 1. PMID 12655004, Free PMC Article
  4. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. Jäkel S, et al. EMBO J, 2002 Feb 1. PMID 11823430, Free PMC Article
  5. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Shen J, et al. Cell Death Differ, 2023 Oct. PMID 37697039, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
    Title: DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC19606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA primary transcript binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mpp10 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mpp10 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP4
Names
IMP4 homolog, U3 small nucleolar ribonucleoprotein
IMP4, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 4 homolog
U3 snoRNP protein IMP4
brix domain-containing protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320304.2 → NP_001307233.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:84 → 251
    Brix; The Brix domain is found in a number of eukaryotic proteins

  2. NM_001320305.2 → NP_001307234.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:84 → 235
    Brix; The Brix domain is found in a number of eukaryotic proteins

  3. NM_001320306.2 → NP_001307235.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    E7ENR5, H0Y714
    Related
    ENSP00000409371.1, ENST00000452955.1
    Conserved Domains (1) summary
    smart00879
    Location:31 → 198
    Brix; The Brix domain is found in a number of eukaryotic proteins

  4. NM_001320307.2 → NP_001307236.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    E7ENR5, H0Y714
    Related
    ENSP00000389701.1, ENST00000428740.5
    Conserved Domains (1) summary
    smart00879
    Location:31 → 198
    Brix; The Brix domain is found in a number of eukaryotic proteins

  5. NM_001320309.2 → NP_001307238.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Related
    ENST00000460766.5
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  6. NM_001320310.2 → NP_001307239.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Related
    ENSP00000386716.1, ENST00000409649.5
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  7. NM_001320311.2 → NP_001307240.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1 → 165
    Brix; The Brix domain is found in a number of eukaryotic proteins

  8. NM_001371725.1 → NP_001358654.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:86 → 281
    Brix; The Brix domain is found in a number of eukaryotic proteins

  9. NM_001371726.1 → NP_001358655.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:86 → 269
    Brix; The Brix domain is found in a number of eukaryotic proteins

  10. NM_001371728.1 → NP_001358657.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B8ZZ47
    Conserved Domains (1) summary
    smart00879
    Location:86 → 252
    Brix; The Brix domain is found in a number of eukaryotic proteins

  11. NM_001371730.1 → NP_001358659.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Conserved Domains (1) summary
    smart00879
    Location:1 → 196
    Brix; The Brix domain is found in a number of eukaryotic proteins

  12. NM_001371731.1 → NP_001358660.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  13. NM_001371732.1 → NP_001358661.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  14. NM_001371733.1 → NP_001358662.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  15. NM_001371734.1 → NP_001358663.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC132479
    UniProtKB/TrEMBL
    B9A008
    Conserved Domains (1) summary
    smart00879
    Location:1 → 168
    Brix; The Brix domain is found in a number of eukaryotic proteins

  16. NM_033416.3 → NP_219484.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

    See identical proteins and their annotated locations for NP_219484.1

    Status: REVIEWED

    Source sequence(s)
    AC132479
    Consensus CDS
    CCDS2160.1
    UniProtKB/Swiss-Prot
    Q3ZTT3, Q96G21
    UniProtKB/TrEMBL
    B8ZZ47
    Related
    ENSP00000259239.3, ENST00000259239.8
    Conserved Domains (1) summary
    smart00879
    Location:86 → 253
    Brix; The Brix domain is found in a number of eukaryotic proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130342897..130347967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    130776821..130781891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96G21.1 GenPept UniProtKB/Swiss-Prot:Q96G21

Gene LinkOut

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