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ZBTB22 zinc finger and BTB domain containing 22 [ Homo sapiens (human) ]

Gene ID: 9278, updated on 18-Aug-2020

Summary

Official Symbol
ZBTB22provided by HGNC
Official Full Name
zinc finger and BTB domain containing 22provided by HGNC
Primary source
HGNC:HGNC:13085
See related
Ensembl:ENSG00000236104 MIM:611439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
fru; BING1; ZNF297; ZBTB22A; ZNF297A; fruitless
Expression
Ubiquitous expression in ovary (RPKM 7.3), thyroid (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB22 in Genome Data Viewer
Location:
6p21.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33314418..33317942, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33282182..33285719, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene TAP binding protein Neighboring gene death domain associated protein Neighboring gene small integral membrane protein 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 22
Names
zinc finger and BTB domain-containing protein 22A
zinc finger protein 297

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145338.2NP_001138810.1  zinc finger and BTB domain-containing protein 22

    See identical proteins and their annotated locations for NP_001138810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK315747, BC018541, BQ002626, DA625357
    Consensus CDS
    CCDS4775.1
    UniProtKB/Swiss-Prot
    O15209
    UniProtKB/TrEMBL
    A0A1U9X8V3
    Related
    ENSP00000404403.1, ENST00000418724.1
    Conserved Domains (4) summary
    sd00017
    Location:488507
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:513535
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:47149
    BTB; BTB/POZ domain
    pfam13465
    Location:527550
    zf-H2C2_2; Zinc-finger double domain
  2. NM_005453.5NP_005444.4  zinc finger and BTB domain-containing protein 22

    See identical proteins and their annotated locations for NP_005444.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL662820, BC018541, BQ002626, BX459194, DA625357, DA777388
    Consensus CDS
    CCDS4775.1
    UniProtKB/Swiss-Prot
    O15209
    UniProtKB/TrEMBL
    A0A1U9X8V3
    Related
    ENSP00000407545.2, ENST00000431845.3
    Conserved Domains (4) summary
    sd00017
    Location:488507
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:513535
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:47149
    BTB; BTB/POZ domain
    pfam13465
    Location:527550
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33314418..33317942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    4725901..4729428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    4557933..4561458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    4750352..4753877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4508845..4512370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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