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BPIFB1 BPI fold containing family B member 1 [ Homo sapiens (human) ]

Gene ID: 92747, updated on 9-Dec-2024

Summary

Official Symbol
BPIFB1provided by HGNC
Official Full Name
BPI fold containing family B member 1provided by HGNC
Primary source
HGNC:HGNC:16108
See related
Ensembl:ENSG00000125999 AllianceGenome:HGNC:16108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPLUNC1; C20orf114
Summary
The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 277.8), lung (RPKM 49.9) and 2 other tissues See more
Orthologs
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Genomic context

See BPIFB1 in Genome Data Viewer
Location:
20q11.21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (33283214..33309871)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (35000716..35037069)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31871020..31897677)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372593 Neighboring gene BPI fold containing family A member 1 Neighboring gene ribosomal protein L12 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31869092-31869592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31869593-31870093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31877426-31878386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31878387-31879347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17727 Neighboring gene uncharacterized LOC124904888 Neighboring gene uncharacterized LOC105372594 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31899476-31899976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31899977-31900477 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31909477-31909976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31911786-31912403 Neighboring gene BPI fold containing family B member 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31934530-31935364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31937032-31937864 Neighboring gene BPI fold containing family B member 9, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
BPI fold-containing family B member 1
Names
VEMSGP
long palate, lung and nasal epithelium carcinoma associated 1
long palate, lung and nasal epithelium carcinoma-associated protein 1
von Ebner minor salivary gland protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033197.3NP_149974.2  BPI fold-containing family B member 1 precursor

    See identical proteins and their annotated locations for NP_149974.2

    Status: REVIEWED

    Source sequence(s)
    AF364078, CD696225
    Consensus CDS
    CCDS13218.1
    UniProtKB/Swiss-Prot
    A8K2H8, Q5QP43, Q6UWY1, Q6ZRU7, Q8TDL5, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
    UniProtKB/TrEMBL
    B2R7Z6
    Related
    ENSP00000253354.1, ENST00000253354.2
    Conserved Domains (2) summary
    cd00025
    Location:26262
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cd00026
    Location:279474
    BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    33283214..33309871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    35000716..35037069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324225.1XP_054180200.1  BPI fold-containing family B member 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K2H8, Q5QP43, Q6UWY1, Q6ZRU7, Q8TDL5, Q96HK6, Q9BQP8, Q9BWZ6, Q9H4V6
    UniProtKB/TrEMBL
    B2R7Z6