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ARRDC1 arrestin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 92714, updated on 6-Sep-2022

Summary

Official Symbol
ARRDC1provided by HGNC
Official Full Name
arrestin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28633
See related
Ensembl:ENSG00000197070 MIM:619768; AllianceGenome:HGNC:28633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables several functions, including arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach (RPKM 15.2), spleen (RPKM 13.5) and 25 other tissues See more
Orthologs
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Genomic context

See ARRDC1 in Genome Data Viewer
Location:
9q34.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137605686..137615360)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149857368..149867042)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140500138..140509812)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902318 Neighboring gene zinc finger MYND-type containing 19 Neighboring gene ARRDC1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6441 Neighboring gene euchromatic histone lysine methyltransferase 1 Neighboring gene SET pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
NOT located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 1
Names
alpha-arrestin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317968.2NP_001304897.1  arrestin domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) retains an intron in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA552336, AK001822, AK308376, AL365502, BI906381
    Conserved Domains (2) summary
    pfam02752
    Location:162283
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_152285.4NP_689498.1  arrestin domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_689498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AA552336, BC032346
    Consensus CDS
    CCDS7049.1
    UniProtKB/Swiss-Prot
    Q8N5I2
    Related
    ENSP00000360475.4, ENST00000371421.9
    Conserved Domains (3) summary
    pfam02752
    Location:162284
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    cl26464
    Location:290428
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137605686..137615360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266119.2XP_005266176.1  arrestin domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    pfam02752
    Location:179300
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:7139
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_047424069.1XP_047280025.1  arrestin domain-containing protein 1 isoform X4

  3. XM_006717320.5XP_006717383.1  arrestin domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam02752
    Location:186307
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:70146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_006717321.5XP_006717384.1  arrestin domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    pfam02752
    Location:186307
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:70146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_006717322.5XP_006717385.1  arrestin domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    pfam02752
    Location:169290
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:70146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  6. XM_017015288.3XP_016870777.1  arrestin domain-containing protein 1 isoform X6

    Conserved Domains (2) summary
    pfam02752
    Location:169290
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:70146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149857368..149867042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)