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CD8B2 CD8b2 molecule [ Homo sapiens (human) ]

Gene ID: 927, updated on 26-Oct-2022

Summary

Official Symbol
CD8B2provided by HGNC
Official Full Name
CD8b2 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1708
See related
Ensembl:ENSG00000254126 AllianceGenome:HGNC:1708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD8BP
Summary
Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CD8B2 in Genome Data Viewer
Location:
2q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (106487364..106544297)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (106948808..107005766)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107103820..107160753)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene plasminogen like A (pseudogene) Neighboring gene RANBP2 like and GRIP domain containing 3 Neighboring gene anaphase-promoting complex subunit 1-like Neighboring gene uncharacterized LOC124907863 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD8 beta-2 chain
Names
CD8 antigen, beta polypeptide pseudogene
CD8b molecule pseudogene
CD8b pseudogene
putative T-cell surface glycoprotein CD8 beta-2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349727.2NP_001336656.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC108868, CA867855, HY085838
    Consensus CDS
    CCDS86870.1
    UniProtKB/Swiss-Prot
    A0A2R8Y7N9
    Related
    ENSP00000496416.1, ENST00000643224.2
    Conserved Domains (1) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
  2. NM_001368307.2NP_001355236.1  T-cell surface glycoprotein CD8 beta-2 chain isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC108868
    Consensus CDS
    CCDS92827.1
    UniProtKB/TrEMBL
    A0A2R8Y6U7
    Related
    ENSP00000495575.1, ENST00000416057.2
    Conserved Domains (1) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    106487364..106544297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453217.2XP_024308985.1  T-cell surface glycoprotein CD8 beta-2 chain isoform X1

    Conserved Domains (1) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    106948808..107005766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002423.4: Suppressed sequence

    Description
    NG_002423.4: This RefSeq was removed because it is now thought this locus is transcribed.