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DTD1 D-aminoacyl-tRNA deacylase 1 [ Homo sapiens (human) ]

Gene ID: 92675, updated on 1-Aug-2020

Summary

Official Symbol
DTD1provided by HGNC
Official Full Name
D-aminoacyl-tRNA deacylase 1provided by HGNC
Primary source
HGNC:HGNC:16219
See related
Ensembl:ENSG00000125821 MIM:610996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; DUEB; DUE-B; HARS2; pqn-68; C20orf88
Summary
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in thyroid (RPKM 7.0), brain (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See DTD1 in Genome Data Viewer
Location:
20p11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (18588054..18766644)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18568556..18744561)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 26 Neighboring gene Sharpr-MPRA regulatory region 13138 Neighboring gene RNA, 7SL, cytoplasmic 638, pseudogene Neighboring gene RNA, U6atac small nuclear 34, pseudogene Neighboring gene double homeobox A pseudogene 7 Neighboring gene DTD1 antisense RNA 1 Neighboring gene uncharacterized LOC107985399 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC41905, MGC119131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA editing activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
 
tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D-aminoacyl-tRNA deacylase 1
Names
D-tyrosyl-tRNA deacylase 1 homolog
D-tyrosyl-tRNA(Tyr) deacylase 1
DNA-unwinding element-binding protein B
gly-tRNA(Ala) deacylase
histidyl-tRNA synthase-related
histidyl-tRNA synthetase 2
NP_001304972.1
NP_543010.3
XP_005260929.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318043.2NP_001304972.1  D-aminoacyl-tRNA deacylase 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074304, AL121900
    Consensus CDS
    CCDS86938.1
    UniProtKB/Swiss-Prot
    Q8TEA8
    Related
    ENSP00000495845.1, ENST00000494921.2
    Conserved Domains (2) summary
    cd00563
    Location:1147
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...
    pfam13900
    Location:165212
    GVQW; Putative domain of unknown function
  2. NM_080820.6NP_543010.3  D-aminoacyl-tRNA deacylase 1 isoform 2

    See identical proteins and their annotated locations for NP_543010.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 3' structure, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AL121780, AW022517, BC100924
    Consensus CDS
    CCDS13138.1
    UniProtKB/Swiss-Prot
    Q8TEA8
    Related
    ENSP00000366672.3, ENST00000377452.3
    Conserved Domains (1) summary
    cd00563
    Location:1147
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    18588054..18766644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260872.4XP_005260929.1  D-aminoacyl-tRNA deacylase 1 isoform X1

    Conserved Domains (1) summary
    cl00253
    Location:1103
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...
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