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DTD1 D-aminoacyl-tRNA deacylase 1 [ Homo sapiens (human) ]

Gene ID: 92675, updated on 4-Dec-2022

Summary

Official Symbol
DTD1provided by HGNC
Official Full Name
D-aminoacyl-tRNA deacylase 1provided by HGNC
Primary source
HGNC:HGNC:16219
See related
Ensembl:ENSG00000125821 MIM:610996; AllianceGenome:HGNC:16219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; DUEB; DUE-B; HARS2; pqn-68; C20orf88
Summary
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in thyroid (RPKM 7.0), brain (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

See DTD1 in Genome Data Viewer
Location:
20p11.23
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18588054..18766644)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18639109..18818510)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18568698..18747288)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904878 Neighboring gene Sharpr-MPRA regulatory region 13138 Neighboring gene small integral membrane protein 26 Neighboring gene RNA, 7SL, cytoplasmic 638, pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6atac small nuclear 34, pseudogene Neighboring gene double homeobox A pseudogene 7 Neighboring gene DTD1 antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 34 Neighboring gene long intergenic non-protein coding RNA 652 Neighboring gene lysosome cell death regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC41905, MGC119131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA binding EXP
Inferred from Experiment
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding EXP
Inferred from Experiment
more info
PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D-aminoacyl-tRNA deacylase 1
Names
D-tyrosyl-tRNA deacylase 1 homolog
D-tyrosyl-tRNA(Tyr) deacylase 1
DNA-unwinding element-binding protein B
gly-tRNA(Ala) deacylase
histidyl-tRNA synthase-related
histidyl-tRNA synthetase 2
NP_001304972.1
NP_543010.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318043.2NP_001304972.1  D-aminoacyl-tRNA deacylase 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074304, AL121900
    Consensus CDS
    CCDS86938.1
    UniProtKB/Swiss-Prot
    Q8TEA8
    UniProtKB/TrEMBL
    A0A2R8Y6X2
    Related
    ENSP00000495845.1, ENST00000494921.2
    Conserved Domains (2) summary
    cd00563
    Location:1147
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...
    pfam13900
    Location:165212
    GVQW; Putative domain of unknown function
  2. NM_080820.6NP_543010.3  D-aminoacyl-tRNA deacylase 1 isoform 2

    See identical proteins and their annotated locations for NP_543010.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 3' structure, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AL121780, AW022517, BC100924
    Consensus CDS
    CCDS13138.1
    UniProtKB/Swiss-Prot
    Q8TEA8, Q9H474
    Related
    ENSP00000366672.4, ENST00000377452.4
    Conserved Domains (1) summary
    cd00563
    Location:1147
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    18588054..18766644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    18639109..18818510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)