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CYTH1 cytohesin 1 [ Homo sapiens (human) ]

Gene ID: 9267, updated on 13-Jan-2020

Summary

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Official Symbol
CYTH1provided by HGNC
Official Full Name
cytohesin 1provided by HGNC
Primary source
HGNC:HGNC:9501
See related
Ensembl:ENSG00000108669 MIM:182115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B2-1; SEC7; PSCD1; D17S811E; CYTOHESIN-1
Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in lymph node (RPKM 26.6), bone marrow (RPKM 23.4) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See CYTH1 in Genome Data Viewer
Location:
17q25.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (78674047..78782342, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76670130..76778376, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 17 Neighboring gene RNA, 7SL, cytoplasmic 454, pseudogene Neighboring gene S-phase cancer associated transcript 1 Neighboring gene uncharacterized LOC112268196 Neighboring gene RNA, U6 small nuclear 638, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr17.5512 Neighboring gene ubiquitin specific peptidase 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells. Rak J, et al. Blood, 2017 Feb 23. PMID 27899358, Free PMC Article
  2. Editorial: Cytohesin-1, on the tail of two integrins. Hyduk SJ, et al. J Leukoc Biol, 2011 Jun. PMID 21628335
  3. B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex. Lee SY, et al. Exp Cell Res, 2000 May 1. PMID 10772823
  4. Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. Nagel W, et al. J Biol Chem, 1998 Jun 12. PMID 9614087
  5. Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Dixon B, et al. Cytogenet Cell Genet, 1993. PMID 8449036

See all (51) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GBF1 alone maintains Golgi architecture; facilitates secretion; activates ADP-ribosylation factor (ARF)1, 3, 4, and 5; and recruits ARF effectors to Golgi membranes.
    Title: Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.
  2. HGF-induced migration depends on the phosphatidylinositol 3,4,5-triphosphate-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.
    Title: HGF-induced migration depends on the PI(3,4,5)P<sub>3</sub>-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.
  3. computational study suggests that although curcumin to some extent binds with Tp receptor, yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD activity in PASMCs.
    Title: Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.
  4. CYTH1 is a novel major regulator of adhesion and engraftment in human hematopoietic stem and progenitor cells through mechanisms that, at least in part, involve the activation of integrins.
    Title: Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.
  5. FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
    Title: FRMD4A-cytohesin signaling modulates the cellular release of tau.
  6. cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells
    Title: Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
  7. findings suggest that cytohesin-1 is a key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on beta2 and beta1 integrin activation
    Title: Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.
  8. involvement of cytohesin-1 in the regulation of the functional responses of human PMNs, linked, in part at least, to the activation of Arf6.
    Title: Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.
  9. demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins
    Title: Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
  10. findings reveal that mycobacteria promote their uptake through a process of "inside-out" signaling involving CD14, TLR2, PI3K, and cytohesin-1. This converts low avidity CR3 into an active receptor leading to increased bacterial internalization
    Title: Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study of co-occurring anxiety in major depression.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34050, FLJ41900

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
establishment of epithelial cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
  
adherens junction IEA
Inferred from Electronic Annotation
more info
  
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
cytosol TAS
Traceable Author Statement
more info
  
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytohesin-1
Names
PH, SEC7 and coiled-coil domain-containing protein 1
SEC7 homolog B2-1
cytoadhesin 1
homolog of secretory protein SEC7
pleckstrin homology, Sec7 and coiled-coil domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292018.1 → NP_001278947.1  cytohesin-1 isoform 3

    See identical proteins and their annotated locations for NP_001278947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon, differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AA030002, AK293894, BC050452
    Consensus CDS
    CCDS86644.1
    UniProtKB/Swiss-Prot
    Q15438
    Related
    ENSP00000466512.1, ENST00000589297.5
    Conserved Domains (2) summary
    cd01252
    Location:200 → 320
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  2. NM_001292019.1 → NP_001278948.1  cytohesin-1 isoform 3

    See identical proteins and their annotated locations for NP_001278948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon, differs in its 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Both variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AA030002, AK316075, BC050452, DA125333
    Consensus CDS
    CCDS86644.1
    UniProtKB/Swiss-Prot
    Q15438
    UniProtKB/TrEMBL
    B7Z9W0
    Related
    ENSP00000465940.1, ENST00000585509.5
    Conserved Domains (2) summary
    cd01252
    Location:200 → 320
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  3. NM_001365037.2 → NP_001351966.1  cytohesin-1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022966, AC099804
    Conserved Domains (2) summary
    cd01252
    Location:259 → 377
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

  4. NM_001365038.2 → NP_001351967.1  cytohesin-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022966, AC099804
    Conserved Domains (2) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  5. NM_001365039.1 → NP_001351968.1  cytohesin-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022966, AC099804
    Conserved Domains (2) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  6. NM_001365040.1 → NP_001351969.1  cytohesin-1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022966, AC099804
    Conserved Domains (2) summary
    cd01252
    Location:261 → 380
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:64 → 246
    Sec7; Sec7 domain

  7. NM_001365041.1 → NP_001351970.1  cytohesin-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC099804
    Conserved Domains (2) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  8. NM_004762.3 → NP_004753.1  cytohesin-1 isoform 1

    See identical proteins and their annotated locations for NP_004753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA030002, AK123894, BC050452, HY049953
    Consensus CDS
    CCDS42392.3
    UniProtKB/Swiss-Prot
    Q15438
    Related
    ENSP00000389095.3, ENST00000446868.7
    Conserved Domains (2) summary
    cd01252
    Location:259 → 379
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

  9. NM_017456.4 → NP_059430.2  cytohesin-1 isoform 2

    See identical proteins and their annotated locations for NP_059430.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA030002, AK123894, BC050452, BX339155, HY049953
    Consensus CDS
    CCDS32754.1
    UniProtKB/Swiss-Prot
    Q15438
    Related
    ENSP00000465665.1, ENST00000591455.5
    Conserved Domains (2) summary
    cd01252
    Location:259 → 378
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    78674047..78782342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525478.2 → XP_011523780.1  cytohesin-1 isoform X6

    Conserved Domains (2) summary
    cd01252
    Location:96 → 216
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:1 → 81
    Sec7; Sec7 domain

  2. XM_024451030.1 → XP_024306798.1  cytohesin-1 isoform X6

    Conserved Domains (2) summary
    cd01252
    Location:96 → 216
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:1 → 81
    Sec7; Sec7 domain

  3. XM_011525476.3 → XP_011523778.1  cytohesin-1 isoform X2

    See identical proteins and their annotated locations for XP_011523778.1

    Conserved Domains (3) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 318
    PH; PH domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  4. XM_011525475.3 → XP_011523777.1  cytohesin-1 isoform X2

    See identical proteins and their annotated locations for XP_011523777.1

    Conserved Domains (3) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 318
    PH; PH domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  5. XM_011525477.1 → XP_011523779.1  cytohesin-1 isoform X4

    See identical proteins and their annotated locations for XP_011523779.1

    UniProtKB/Swiss-Prot
    Q15438
    Conserved Domains (2) summary
    cd01252
    Location:200 → 320
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15438.1 GenPept UniProtKB/Swiss-Prot:Q15438

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