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TIFA TRAF interacting protein with forkhead associated domain [ Homo sapiens (human) ]

Gene ID: 92610, updated on 1-Jun-2020

Summary

Official Symbol
TIFAprovided by HGNC
Official Full Name
TRAF interacting protein with forkhead associated domainprovided by HGNC
Primary source
HGNC:HGNC:19075
See related
Ensembl:ENSG00000145365 MIM:609028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2BP; T6BP; TIFAA
Summary
This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]
Expression
Ubiquitous expression in lymph node (RPKM 11.2), thyroid (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See TIFA in Genome Data Viewer
Location:
4q25
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112274537..112285904, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113196782..113207059, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 241 member A Neighboring gene ribosomal protein L36a pseudogene 19 Neighboring gene adaptor related protein complex 1 associated regulatory protein Neighboring gene Sharpr-MPRA regulatory region 9995 Neighboring gene alpha kinase 1 Neighboring gene regulator of telomere elongation helicase 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TRAF-interacting protein with FHA domain-containing protein A
Names
TRAF-interacting protein with a forkhead-associated domain
TRAF2 binding protein
TRAF6 binding protein
putative MAPK-activating protein PM14
putative NF-kappa-B-activating protein 20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052864.3NP_443096.1  TRAF-interacting protein with FHA domain-containing protein A

    See identical proteins and their annotated locations for NP_443096.1

    Status: REVIEWED

    Source sequence(s)
    AB097011, AC109347, BM680110, BM718895, CA772080
    Consensus CDS
    CCDS34051.1
    UniProtKB/Swiss-Prot
    Q96CG3
    Related
    ENSP00000354911.2, ENST00000361717.4
    Conserved Domains (1) summary
    cd00060
    Location:41128
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    112274537..112285904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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