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CD8B CD8b molecule [ Homo sapiens (human) ]

Gene ID: 926, updated on 17-Jun-2019

Summary

Official Symbol
CD8Bprovided by HGNC
Official Full Name
CD8b moleculeprovided by HGNC
Primary source
HGNC:HGNC:1707
See related
Ensembl:ENSG00000172116 MIM:186730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY3; P37; LEU2; LYT3; CD8B1
Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
Expression
Broad expression in lymph node (RPKM 4.6), small intestine (RPKM 2.3) and 14 other tissues See more
Orthologs

Genomic context

See CD8B in Genome Data Viewer
Location:
2p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (86815337..86861924, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87042460..87089047, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene CD8A intronic regulatory region Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8a molecule Neighboring gene anaphase promoting complex subunit 1 pseudogene 1 Neighboring gene WW domain binding protein 1 pseudogene Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
Nef nef HIV-1 Nef downregulates surface expression of the beta-chain of the CD8 receptor by accelerated endocytosis; amino acid positions 57 to 58 and 174 to 175 in Nef are involved in the down modulation PubMed
nef HIV-1 Nef interaction with AP-1gamma is required for CD28 and CD8beta downregulation PubMed
nef Downregulation of CD8beta by HIV-1 Nef requires an intact AP-2 complex PubMed
nef Co-localization of HIV-1 Nef and CD8beta is revealed by staining assays in 293T cells expressing both proteins PubMed
Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I protein binding NAS
Non-traceable Author Statement
more info
PubMed 
coreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
T cell receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD8 beta chain
Names
CD8 antigen, beta polypeptide 1 (p37)
T lymphocyte surface glycoprotein beta chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178100.1NP_001171571.1  T-cell surface glycoprotein CD8 beta chain isoform 6 precursor

    See identical proteins and their annotated locations for NP_001171571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13445
    Consensus CDS
    CCDS54376.1
    UniProtKB/Swiss-Prot
    P10966
    Related
    ENSP00000377358.2, ENST00000393761.6
    Conserved Domains (2) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26134
    IG_like; Immunoglobulin like
  2. NM_004931.5NP_004922.1  T-cell surface glycoprotein CD8 beta chain isoform 5 precursor

    See identical proteins and their annotated locations for NP_004922.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AC111200, BC100912, BP392114, DB223179, DC405359, X13444
    Consensus CDS
    CCDS1997.1
    UniProtKB/Swiss-Prot
    P10966
    Related
    ENSP00000375070.6, ENST00000390655.11
    Conserved Domains (2) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26134
    IG_like; Immunoglobulin like
  3. NM_172101.4NP_742099.1  T-cell surface glycoprotein CD8 beta chain isoform 3 precursor

    See identical proteins and their annotated locations for NP_742099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13445
    Consensus CDS
    CCDS42708.1
    UniProtKB/Swiss-Prot
    P10966
    Related
    ENSP00000377356.2, ENST00000393759.6
    Conserved Domains (2) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26134
    IG_like; Immunoglobulin like
  4. NM_172102.4NP_742100.1  T-cell surface glycoprotein CD8 beta chain isoform 4 precursor

    See identical proteins and their annotated locations for NP_742100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2.
    Source sequence(s)
    AW296309, BC100912, DC405359, X13446
    Consensus CDS
    CCDS1994.1
    UniProtKB/Swiss-Prot
    P10966
    Related
    ENSP00000340592.3, ENST00000349455.7
    Conserved Domains (2) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26134
    IG_like; Immunoglobulin like
  5. NM_172213.4NP_757362.1  T-cell surface glycoprotein CD8 beta chain isoform 2 precursor

    See identical proteins and their annotated locations for NP_757362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AW296309, BC100912, BC100913, DC405359
    Consensus CDS
    CCDS1995.1
    UniProtKB/Swiss-Prot
    P10966
    Related
    ENSP00000331172.2, ENST00000331469.6
    Conserved Domains (1) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    86815337..86861924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533164.2XP_011531466.1  T-cell surface glycoprotein CD8 beta chain isoform X1

    See identical proteins and their annotated locations for XP_011531466.1

    UniProtKB/TrEMBL
    Q53QL8
    Conserved Domains (2) summary
    cd07700
    Location:29134
    IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain
    smart00410
    Location:26134
    IG_like; Immunoglobulin like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172099.2: Suppressed sequence

    Description
    NM_172099.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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