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ASB16 ankyrin repeat and SOCS box containing 16 [ Homo sapiens (human) ]

Gene ID: 92591, updated on 24-Nov-2020

Summary

Official Symbol
ASB16provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 16provided by HGNC
Primary source
HGNC:HGNC:19768
See related
Ensembl:ENSG00000161664 MIM:615056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 1.6), prostate (RPKM 1.5) and 25 other tissues See more
Orthologs

Genomic context

See ASB16 in Genome Data Viewer
Location:
17q21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (44170704..44179084)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42248074..42256650)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 131, pseudogene Neighboring gene homologous recombination factor with OB-fold Neighboring gene ASB16 antisense RNA 1 Neighboring gene transmembrane and ubiquitin like domain containing 2 Neighboring gene ataxin 7 like 3 Neighboring gene Sharpr-MPRA regulatory region 8559

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30165, MGC141876, MGC141877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 16
Names
ankyrin repeat and SOCS box-containing protein 16

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080863.5NP_543139.4  ankyrin repeat and SOCS box protein 16

    See identical proteins and their annotated locations for NP_543139.4

    Status: REVIEWED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11478.1
    UniProtKB/Swiss-Prot
    Q96NS5
    Related
    ENSP00000293414.1, ENST00000293414.6
    Conserved Domains (4) summary
    cd00204
    Location:114228
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03716
    Location:406447
    SOCS_ASB_like; SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable ...
    pfam12796
    Location:147239
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:143173
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    44170704..44179084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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