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BICDL1 BICD family like cargo adaptor 1 [ Homo sapiens (human) ]

Gene ID: 92558, updated on 5-Aug-2022

Summary

Official Symbol
BICDL1provided by HGNC
Official Full Name
BICD family like cargo adaptor 1provided by HGNC
Primary source
HGNC:HGNC:28095
See related
Ensembl:ENSG00000135127 MIM:617002; AllianceGenome:HGNC:28095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BICDR1; CCDC64; BICDR-1; CCDC64A; H_267D11.1
Summary
Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport; neuron projection development; and vesicle transport along microtubule. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 26.8), skin (RPKM 12.5) and 9 other tissues See more
Orthologs
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Genomic context

See BICDL1 in Genome Data Viewer
Location:
12q24.23
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119989236..120094495)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119976368..120081656)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120427040..120532299)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene citron rho-interacting serine/threonine kinase Neighboring gene microRNA 1178 Neighboring gene uncharacterized LOC112268087 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB35, member RAS oncogene family Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 4498

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynactin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in Golgi to secretory granule transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi to secretory granule transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BICD family-like cargo adapter 1
Names
BICD-related protein 1
bicaudal D-related protein 1
coiled-coil domain containing 64
coiled-coil domain-containing protein 64A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367886.1NP_001354815.1  BICD family-like cargo adapter 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815
    Related
    ENSP00000447477.2, ENST00000548673.6
  2. NM_207311.2NP_997194.2  BICD family-like cargo adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_997194.2

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815, AK129960, U88834
    Consensus CDS
    CCDS41845.1
    UniProtKB/Swiss-Prot
    O95000, Q6ZP65
    Related
    ENSP00000380690.2, ENST00000397558.6
    Conserved Domains (2) summary
    pfam14988
    Location:120296
    DUF4515; Domain of unknown function (DUF4515)
    cl19252
    Location:167295
    MreC; rod shape-determining protein MreC

RNA

  1. NR_147892.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815
  2. NR_147893.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815
  3. NR_147894.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004812, AC004815

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    119989236..120094495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719694.4XP_006719757.1  BICD family-like cargo adapter 1 isoform X1

    Conserved Domains (2) summary
    pfam14988
    Location:120300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_006719696.4XP_006719759.1  BICD family-like cargo adapter 1 isoform X5

    Conserved Domains (2) summary
    pfam14988
    Location:120300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_006719697.4XP_006719760.1  BICD family-like cargo adapter 1 isoform X7

    Conserved Domains (2) summary
    pfam01665
    Location:99264
    Rota_NSP3; Rotavirus non-structural protein NSP3
    pfam14988
    Location:120300
    DUF4515; Domain of unknown function (DUF4515)
  4. XM_047429890.1XP_047285846.1  BICD family-like cargo adapter 1 isoform X8

  5. XM_047429887.1XP_047285843.1  BICD family-like cargo adapter 1 isoform X3

  6. XM_011538999.3XP_011537301.1  BICD family-like cargo adapter 1 isoform X2

    Conserved Domains (2) summary
    pfam14988
    Location:120300
    DUF4515; Domain of unknown function (DUF4515)
    cl23720
    Location:164279
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  7. XM_047429889.1XP_047285845.1  BICD family-like cargo adapter 1 isoform X6

  8. XM_047429888.1XP_047285844.1  BICD family-like cargo adapter 1 isoform X4

  9. XM_011539000.2XP_011537302.1  BICD family-like cargo adapter 1 isoform X9

    See identical proteins and their annotated locations for XP_011537302.1

    Conserved Domains (1) summary
    TIGR02168
    Location:54379
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  10. XM_047429891.1XP_047285847.1  BICD family-like cargo adapter 1 isoform X10

RNA

  1. XR_007063143.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    119976368..120081656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)