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AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [ Homo sapiens (human) ]

Gene ID: 9255, updated on 4-Oct-2020

Summary

Official Symbol
AIMP1provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 1provided by HGNC
Primary source
HGNC:HGNC:10648
See related
Ensembl:ENSG00000164022 MIM:603605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p43; HLD3; EMAP2; SCYE1; EMAPII
Summary
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See AIMP1 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (106315544..106349456)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (107236767..107270382)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929577 Neighboring gene Sharpr-MPRA regulatory region 11278 Neighboring gene TBC1 domain containing kinase Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene long intergenic non-protein coding RNA 2173

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Tat tat SCYE1 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Names
ARS-interacting multifunctional protein 1
endothelial monocyte-activating polypeptide 2
endothelial-monocyte activating polypeptide II
multisynthase complex auxiliary component p43
multisynthetase complex auxiliary component p43
small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028166.1 RefSeqGene

    Range
    5001..38616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142415.2NP_001135887.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001135887.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC093680, AK297950, BC014051, BM314663, BQ447202, DC358150
    Consensus CDS
    CCDS3674.1
    UniProtKB/Swiss-Prot
    Q12904
    UniProtKB/TrEMBL
    B4DNK3
    Related
    ENSP00000405248.1, ENST00000442366.5
    Conserved Domains (2) summary
    PLN02610
    Location:140312
    PLN02610; probable methionyl-tRNA synthetase
    PRK05431
    Location:379
    PRK05431; seryl-tRNA synthetase; Provisional
  2. NM_001142416.2NP_001135888.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and includes an additional segment in the 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC093680, AK303965, U10117
    Consensus CDS
    CCDS47121.1
    Related
    ENSP00000500620.1, ENST00000672341.1
    Conserved Domains (2) summary
    PLN02610
    Location:140312
    PLN02610; probable methionyl-tRNA synthetase
    PRK05431
    Location:379
    PRK05431; seryl-tRNA synthetase; Provisional
  3. NM_004757.4NP_004748.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_004748.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC093680, AK095951, BC014051, BG941396, BM314663, BQ447202, DA211424
    Consensus CDS
    CCDS3674.1
    UniProtKB/Swiss-Prot
    Q12904
    Related
    ENSP00000350699.3, ENST00000358008.7
    Conserved Domains (2) summary
    PLN02610
    Location:140312
    PLN02610; probable methionyl-tRNA synthetase
    PRK05431
    Location:379
    PRK05431; seryl-tRNA synthetase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    106315544..106349456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008835.2XP_016864324.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12904
    Related
    ENSP00000500025.1, ENST00000671960.1
    Conserved Domains (2) summary
    PLN02610
    Location:140312
    PLN02610; probable methionyl-tRNA synthetase
    PRK05431
    Location:379
    PRK05431; seryl-tRNA synthetase; Provisional
  2. XM_017008836.2XP_016864325.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12904
    Related
    ENSP00000500732.1, ENST00000673018.1
    Conserved Domains (2) summary
    PLN02610
    Location:140312
    PLN02610; probable methionyl-tRNA synthetase
    PRK05431
    Location:379
    PRK05431; seryl-tRNA synthetase; Provisional
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