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RPS6KA5 ribosomal protein S6 kinase A5 [ Homo sapiens (human) ]

Gene ID: 9252, updated on 7-Dec-2018

Summary

Official Symbol
RPS6KA5provided by HGNC
Official Full Name
ribosomal protein S6 kinase A5provided by HGNC
Primary source
HGNC:HGNC:10434
See related
Ensembl:ENSG00000100784 MIM:603607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK1; RLPK; MSPK1
Expression
Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See RPS6KA5 in Genome Data Viewer
Location:
14q32.11
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (90868122..91060649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91335086..91526993, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene ribosomal protein S18 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2321 Neighboring gene D-glutamate cyclase Neighboring gene RNA, U7 small nuclear 30 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5, MSK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Bladder Cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, organism-specific biosystem (from KEGG)
    Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, conserved biosystem (from KEGG)
    Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
    C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
  • CD209 (DC-SIGN) signaling, organism-specific biosystem (from REACTOME)
    CD209 (DC-SIGN) signaling, organism-specific biosystemCD209 (also called as DC-SIGN (DC-specific intracellular adhesion molecule-3-grabbing non-integrin)) is a type II transmembrane C-type lectin receptor preferentially expressed on dendritic cells (DCs...
  • CREB phosphorylation, organism-specific biosystem (from REACTOME)
    CREB phosphorylation, organism-specific biosystemNerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial ...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • ERK Pathway in Huntington's Disease, organism-specific biosystem (from WikiPathways)
    ERK Pathway in Huntington's Disease, organism-specific biosystemThis ERK pathway is implicated in Huntington's Disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS...
  • ERK/MAPK targets, organism-specific biosystem (from REACTOME)
    ERK/MAPK targets, organism-specific biosystemERK/MAPK kinases have a number of targets within the nucleus, usually transcription factors or other kinases. The best known targets, ELK1, ETS1, ATF2, MITF, MAPKAPK2, MSK1, RSK1/2/3 and MEF2 are ann...
  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Interferon type I signaling pathways, organism-specific biosystem (from WikiPathways)
    Interferon type I signaling pathways, organism-specific biosystemThe type I IFNs (IFN? family, IFN?, IFN?, IFN? and IFN?) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • LPA4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LPA4-mediated signaling events, organism-specific biosystem
    LPA4-mediated signaling events
  • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
    MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
    MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemMAPKs are protein kinases that, once activated, phosphorylate their specific cytosolic or nuclear substrates at serine and/or threonine residues. Such phosphorylation events can either positively or ...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Nuclear Events (kinase and transcription factor activation), organism-specific biosystem (from REACTOME)
    Nuclear Events (kinase and transcription factor activation), organism-specific biosystemAn important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene express...
  • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
    Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
  • Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystem (from WikiPathways)
    Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
    Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem (from Pathway Interaction Database)
    Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem
    Trk receptor signaling mediated by the MAPK pathway
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
histone H2A-S1 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-S10 phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-S28 phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
histone phosphorylation TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine production TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of CREB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-5
Names
90 kDa ribosomal protein S6 kinase 5
RSK-like protein kinase
RSKL
S6K-alpha-5
nuclear mitogen- and stress-activated protein kinase 1
ribosomal protein S6 kinase, 90kDa, polypeptide 5
NP_001309156.1
NP_001309157.1
NP_001309158.1
NP_001309159.1
NP_001309160.1
NP_001309161.1
NP_001309162.1
NP_001309163.1
NP_001309164.1
NP_001309165.1
NP_001309166.1
NP_001309167.1
NP_004746.2
NP_872198.1
XP_016877275.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322227.1NP_001309156.1  ribosomal protein S6 kinase alpha-5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:149406
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:137446
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001322228.1NP_001309157.1  ribosomal protein S6 kinase alpha-5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (4) summary
    smart00133
    Location:284343
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:394651
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:382691
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:48301
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001322229.1NP_001309158.1  ribosomal protein S6 kinase alpha-5 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (4) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:49318
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cd14179
    Location:418720
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  4. NM_001322230.1NP_001309159.1  ribosomal protein S6 kinase alpha-5 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd14179
    Location:151460
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:2113
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001322231.1NP_001309160.1  ribosomal protein S6 kinase alpha-5 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:191448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:179488
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:7141
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001322232.1NP_001309161.1  ribosomal protein S6 kinase alpha-5 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (4) summary
    smart00133
    Location:247306
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:357614
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:345654
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:59264
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001322233.1NP_001309162.1  ribosomal protein S6 kinase alpha-5 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd05583
    Location:54320
    STKc_MSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase
    cd14179
    Location:364673
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  8. NM_001322234.1NP_001309163.1  ribosomal protein S6 kinase alpha-5 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:238495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:226535
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:16188
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001322235.1NP_001309164.1  ribosomal protein S6 kinase alpha-5 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS81839.1
    UniProtKB/Swiss-Prot
    O75582
    Conserved Domains (3) summary
    smart00133
    Location:241300
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd14179
    Location:339648
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001322236.1NP_001309165.1  ribosomal protein S6 kinase alpha-5 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:402659
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:390699
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:48352
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001322237.1NP_001309166.1  ribosomal protein S6 kinase alpha-5 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS81839.1
    UniProtKB/Swiss-Prot
    O75582
    Related
    ENSP00000442803.2, ENST00000536315.6
    Conserved Domains (3) summary
    smart00133
    Location:241300
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd14179
    Location:339648
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001322238.1NP_001309167.1  ribosomal protein S6 kinase alpha-5 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd14179
    Location:199508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1161
    PKc_like; Protein Kinases, catalytic domain
  13. NM_004755.4NP_004746.2  ribosomal protein S6 kinase alpha-5 isoform a

    See identical proteins and their annotated locations for NP_004746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS9893.1
    UniProtKB/Swiss-Prot
    O75582
    Related
    ENSP00000479667.1, ENST00000614987.4
    Conserved Domains (3) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cd14179
    Location:418727
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  14. NM_182398.2NP_872198.1  ribosomal protein S6 kinase alpha-5 isoform b

    See identical proteins and their annotated locations for NP_872198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame segment in the 3' coding region, compared to variant 1. Isoform b has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AL121784, AL133454
    Consensus CDS
    CCDS45149.1
    UniProtKB/Swiss-Prot
    O75582
    Related
    ENSP00000402787.2, ENST00000418736.6
    Conserved Domains (3) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:418548
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    90868122..91060649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021786.2XP_016877275.1  ribosomal protein S6 kinase alpha-5 isoform X1

    Conserved Domains (2) summary
    cd14179
    Location:199508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1161
    PKc_like; Protein Kinases, catalytic domain
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