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RPS6KA5 ribosomal protein S6 kinase A5 [ Homo sapiens (human) ]

Gene ID: 9252, updated on 22-Sep-2022

Summary

Official Symbol
RPS6KA5provided by HGNC
Official Full Name
ribosomal protein S6 kinase A5provided by HGNC
Primary source
HGNC:HGNC:10434
See related
Ensembl:ENSG00000100784 MIM:603607; AllianceGenome:HGNC:10434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK1; RLPK; MSPK1
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See RPS6KA5 in Genome Data Viewer
Location:
14q32.11
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (90847861..91060641, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (85073446..85286084, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91314205..91526985, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene ribosomal protein S18 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2321 Neighboring gene D-glutamate cyclase Neighboring gene RNA, U7 small nuclear 30 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5, MSK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H2AS1 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3S10 kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3S28 kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance TAS
Traceable Author Statement
more info
 
involved_in histone modification IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokine production TAS
Traceable Author Statement
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CREB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-translational protein modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-5
Names
90 kDa ribosomal protein S6 kinase 5
RSK-like protein kinase
RSKL
S6K-alpha-5
nuclear mitogen- and stress-activated protein kinase 1
ribosomal protein S6 kinase, 90kDa, polypeptide 5
NP_001309156.1
NP_001309157.1
NP_001309158.1
NP_001309159.1
NP_001309160.1
NP_001309161.1
NP_001309162.1
NP_001309163.1
NP_001309164.1
NP_001309165.1
NP_001309166.1
NP_001309167.1
NP_004746.2
NP_872198.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322227.2NP_001309156.1  ribosomal protein S6 kinase alpha-5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:149406
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:137446
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001322228.2NP_001309157.1  ribosomal protein S6 kinase alpha-5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00133
    Location:284343
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd14179
    Location:382691
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:48301
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001322229.2NP_001309158.1  ribosomal protein S6 kinase alpha-5 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cd14179
    Location:418720
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  4. NM_001322230.2NP_001309159.1  ribosomal protein S6 kinase alpha-5 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd14179
    Location:151460
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:2113
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001322231.2NP_001309160.1  ribosomal protein S6 kinase alpha-5 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:191448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:179488
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:7141
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001322232.2NP_001309161.1  ribosomal protein S6 kinase alpha-5 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (4) summary
    smart00133
    Location:247306
    S_TK_X; Extension to Ser/Thr-type protein kinases
    smart00220
    Location:357614
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:345654
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:59264
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001322233.2NP_001309162.1  ribosomal protein S6 kinase alpha-5 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd05583
    Location:54320
    STKc_MSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase
    cd14179
    Location:364673
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  8. NM_001322234.2NP_001309163.1  ribosomal protein S6 kinase alpha-5 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:238495
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:226535
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:16188
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001322235.2NP_001309164.1  ribosomal protein S6 kinase alpha-5 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS81839.1
    UniProtKB/Swiss-Prot
    O75582
    Conserved Domains (3) summary
    smart00133
    Location:241300
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd14179
    Location:339648
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001322236.2NP_001309165.1  ribosomal protein S6 kinase alpha-5 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (3) summary
    smart00220
    Location:402659
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:390699
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:48352
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001322237.2NP_001309166.1  ribosomal protein S6 kinase alpha-5 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS81839.1
    UniProtKB/Swiss-Prot
    O75582
    Related
    ENSP00000442803.2, ENST00000536315.6
    Conserved Domains (3) summary
    smart00133
    Location:241300
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd14179
    Location:339648
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001322238.2NP_001309167.1  ribosomal protein S6 kinase alpha-5 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL133454, AL159191
    Conserved Domains (2) summary
    cd14179
    Location:199508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1161
    PKc_like; Protein Kinases, catalytic domain
  13. NM_004755.4NP_004746.2  ribosomal protein S6 kinase alpha-5 isoform a

    See identical proteins and their annotated locations for NP_004746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL121784, AL133454, AL159191
    Consensus CDS
    CCDS9893.1
    UniProtKB/Swiss-Prot
    O75582, Q96AF7
    Related
    ENSP00000479667.1, ENST00000614987.5
    Conserved Domains (3) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cd14179
    Location:418727
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
  14. NM_182398.3NP_872198.1  ribosomal protein S6 kinase alpha-5 isoform b

    See identical proteins and their annotated locations for NP_872198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame segment in the 3' coding region, compared to variant 1. Isoform b has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AL121784, AL133454
    Consensus CDS
    CCDS45149.1
    UniProtKB/Swiss-Prot
    O75582
    Related
    ENSP00000402787.2, ENST00000418736.6
    Conserved Domains (3) summary
    smart00133
    Location:320379
    S_TK_X; Extension to Ser/Thr-type protein kinases
    cd05613
    Location:48337
    STKc_MSK1_N; N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:418548
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    90847861..91060641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    85073446..85286084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)