Format

Send to:

Choose Destination

GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type [ Homo sapiens (human) ]

Gene ID: 9245, updated on 13-Mar-2020

Summary

Official Symbol
GCNT3provided by HGNC
Official Full Name
glucosaminyl (N-acetyl) transferase 3, mucin typeprovided by HGNC
Primary source
HGNC:HGNC:4205
See related
Ensembl:ENSG00000140297 MIM:606836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT
Summary
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Expression
Biased expression in colon (RPKM 74.9), small intestine (RPKM 64.2) and 7 other tissues See more
Orthologs

Genomic context

See GCNT3 in Genome Data Viewer
Location:
15q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (59611783..59622723)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59903982..59912210)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 117 Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene general transcription factor IIA subunit 2 Neighboring gene BCL2 interacting protein 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glucosaminyl (N-acetyl) transferase 3, mucin type (GCNT3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
immunoglobulin production in mucosal tissue IEA
Inferred from Electronic Annotation
more info
 
intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
kidney morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
Names
C2GnT-mucin type
beta1,6-N-acetylglucosaminyltransferase-M
beta1,6GlcNAc-transferase
core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
hC2GnT-M
mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
NP_004742.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004751.3NP_004742.1  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

    See identical proteins and their annotated locations for NP_004742.1

    Status: REVIEWED

    Source sequence(s)
    AC092755, BC017032, BP243086
    Consensus CDS
    CCDS10172.1
    UniProtKB/Swiss-Prot
    O95395
    UniProtKB/TrEMBL
    A0A024R5T9
    Related
    ENSP00000379377.1, ENST00000396065.3
    Conserved Domains (1) summary
    pfam02485
    Location:133401
    Branch; Core-2/I-Branching enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    59611783..59622723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center