Format

Send to:

Choose Destination

CRLF1 cytokine receptor like factor 1 [ Homo sapiens (human) ]

Gene ID: 9244, updated on 1-Aug-2020

Summary

Official Symbol
CRLF1provided by HGNC
Official Full Name
cytokine receptor like factor 1provided by HGNC
Primary source
HGNC:HGNC:2364
See related
Ensembl:ENSG00000006016 MIM:604237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLF; NR6; CISS; CISS1; CLF-1; zcytor5
Summary
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Expression
Broad expression in placenta (RPKM 4.8), brain (RPKM 3.2) and 15 other tissues See more
Orthologs

Genomic context

See CRLF1 in Genome Data Viewer
Location:
19p13.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18593237..18606799, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18704035..18717660, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene transmembrane protein 59 like Neighboring gene RNA, 7SL, cytoplasmic 155, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of cytokine receptor-like factor 1 (CRLF1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
CRLF-CLCF1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CRLF-CLCF1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytokine receptor-like factor 1
Names
class I cytokine receptor
cytokine type 1 receptor CRLP-1
cytokine-like factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013370.1 RefSeqGene

    Range
    5052..18614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004750.5NP_004741.1  cytokine receptor-like factor 1 precursor

    See identical proteins and their annotated locations for NP_004741.1

    Status: REVIEWED

    Source sequence(s)
    AF073515, AY358291
    Consensus CDS
    CCDS32962.1
    UniProtKB/Swiss-Prot
    O75462
    Related
    ENSP00000376188.2, ENST00000392386.8
    Conserved Domains (3) summary
    cd00063
    Location:236338
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:41104
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:133228
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18593237..18606799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center