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MRRF mitochondrial ribosome recycling factor [ Homo sapiens (human) ]

Gene ID: 92399, updated on 7-Jun-2020

Summary

Official Symbol
MRRFprovided by HGNC
Official Full Name
mitochondrial ribosome recycling factorprovided by HGNC
Primary source
HGNC:HGNC:7234
See related
Ensembl:ENSG00000148187 MIM:604602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRF; MRFF; MTRRF
Summary
This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in testis (RPKM 8.8), duodenum (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See MRRF in Genome Data Viewer
Location:
9q33.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (122264603..122331337)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125026882..125085743)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3979 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox 6 Neighboring gene RNA binding motif protein 18 Neighboring gene prostaglandin-endoperoxide synthase 1 Neighboring gene olfactory receptor family 1 subfamily J member 2 Neighboring gene olfactory receptor family 1 subfamily J member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosome-recycling factor, mitochondrial
Names
ribosome-releasing factor, mitochondrial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051806.1 RefSeqGene

    Range
    5001..65713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173512.2NP_001166983.1  ribosome-recycling factor, mitochondrial isoform 3 precursor

    See identical proteins and their annotated locations for NP_001166983.1

    Status: REVIEWED

    Source sequence(s)
    AA873020, AK300718, AK310974, AL162424, BC013049
    Consensus CDS
    CCDS55336.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000297908.3, ENST00000297908.7
    Conserved Domains (1) summary
    pfam01765
    Location:64208
    RRF; Ribosome recycling factor
  2. NM_001346339.2NP_001333268.1  ribosome-recycling factor, mitochondrial isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AA873020, AL162424
  3. NM_001346341.2NP_001333270.1  ribosome-recycling factor, mitochondrial isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AA873020, AL162424
    Consensus CDS
    CCDS6840.1
    UniProtKB/Swiss-Prot
    Q96E11
    Conserved Domains (1) summary
    pfam01765
    Location:103260
    RRF; Ribosome recycling factor
  4. NM_001346343.2NP_001333272.1  ribosome-recycling factor, mitochondrial isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA873020, AK300718, AL162424, BI756457
    Consensus CDS
    CCDS87684.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000362834.1, ENST00000373729.5
  5. NM_001346345.2NP_001333274.1  ribosome-recycling factor, mitochondrial isoform 6

    Status: REVIEWED

    Source sequence(s)
    AA873020, AL162424
  6. NM_001346347.2NP_001333276.1  ribosome-recycling factor, mitochondrial isoform 7

    Status: REVIEWED

    Source sequence(s)
    AA873020, AL162424
  7. NM_138777.5NP_620132.1  ribosome-recycling factor, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_620132.1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AA873020, AK291603, AL162424, BC013049
    Consensus CDS
    CCDS6840.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000343867.3, ENST00000344641.8
    Conserved Domains (1) summary
    pfam01765
    Location:103260
    RRF; Ribosome recycling factor
  8. NM_199177.4NP_954646.1  ribosome-recycling factor, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_954646.1

    Status: REVIEWED

    Source sequence(s)
    AA873020, AK291603, AL162424, BC013049, BC053604, BU543762
    Consensus CDS
    CCDS48013.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000362828.4, ENST00000373723.9
    Conserved Domains (1) summary
    pfam01765
    Location:110192
    RRF; Ribosome recycling factor

RNA

  1. NR_144421.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA873020, AL162424

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    122264603..122331337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519185.3XP_011517487.1  ribosome-recycling factor, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam01765
    Location:131213
    RRF; Ribosome recycling factor
  2. XM_017015286.2XP_016870775.1  ribosome-recycling factor, mitochondrial isoform X3

  3. XM_011519183.2XP_011517485.1  ribosome-recycling factor, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011517485.1

    Conserved Domains (1) summary
    pfam01765
    Location:131281
    RRF; Ribosome recycling factor

RNA

  1. XR_001746417.2 RNA Sequence

  2. XR_001746416.2 RNA Sequence

  3. XR_428543.4 RNA Sequence

  4. XR_002956824.1 RNA Sequence

  5. XR_002956825.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199176.1: Suppressed sequence

    Description
    NM_199176.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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