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TBRG4 transforming growth factor beta regulator 4 [ Homo sapiens (human) ]

Gene ID: 9238, updated on 21-Dec-2017
Official Symbol
TBRG4provided by HGNC
Official Full Name
transforming growth factor beta regulator 4provided by HGNC
Primary source
HGNC:HGNC:17443
See related
Ensembl:ENSG00000136270 MIM:611325; Vega:OTTHUMG00000129247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPR2; FASTKD4
Expression
Ubiquitous expression in testis (RPKM 18.2), duodenum (RPKM 14.9) and 25 other tissues See more
Orthologs
Location:
7p13
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (45100100..45111747, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45139699..45151346, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723334 Neighboring gene CCM2 scaffolding protein Neighboring gene NAC alpha domain containing Neighboring gene small nucleolar RNA, H/ACA box 5A Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene small nucleolar RNA, H/ACA box 5B Neighboring gene receptor activity modifying protein 3 Neighboring gene uncharacterized LOC107986736

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with transforming growth factor beta regulator 4 (TBRG4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cellular respiration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial mRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein TBRG4
Names
FAST kinase domain-containing protein 4
FAST kinase domains 4
H_TD2522F11.8
cell cycle progression protein 2
cell cycle progression restoration protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261834.1NP_001248763.1  protein TBRG4 isoform 3

    See identical proteins and their annotated locations for NP_001248763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at an upstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298155, AK300489, BM150942, DA980367
    UniProtKB/TrEMBL
    B3KRS4, B4DU42
    Conserved Domains (3) summary
    smart00952
    Location:574631
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:381447
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:465546
    FAST_2; FAST kinase-like protein, subdomain 2
  2. NM_004749.3NP_004740.2  protein TBRG4 isoform 1

    See identical proteins and their annotated locations for NP_004740.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC017235, BM150942, DA980367
    Consensus CDS
    CCDS5501.1
    UniProtKB/Swiss-Prot
    Q969Z0
    Related
    ENSP00000258770.3, OTTHUMP00000159557, ENST00000258770.7, OTTHUMT00000251351
    Conserved Domains (3) summary
    smart00952
    Location:563620
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:370436
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:454535
    FAST_2; FAST kinase-like protein, subdomain 2
  3. NM_030900.3NP_112162.1  protein TBRG4 isoform 2

    See identical proteins and their annotated locations for NP_112162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AB023165, AK222943, BM150942, DA980367
    Consensus CDS
    CCDS5502.1
    UniProtKB/Swiss-Prot
    Q969Z0
    Related
    ENSP00000354992.3, OTTHUMP00000159555, ENST00000361278.7, OTTHUMT00000251349
    Conserved Domains (3) summary
    smart00952
    Location:453510
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:260326
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:344425
    FAST_2; FAST kinase-like protein, subdomain 2
  4. NM_199122.2NP_954573.1  protein TBRG4 isoform 2

    See identical proteins and their annotated locations for NP_954573.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK001281, BM150942, DA980367
    Consensus CDS
    CCDS5502.1
    UniProtKB/Swiss-Prot
    Q969Z0
    UniProtKB/TrEMBL
    B3KM73
    Related
    ENSP00000379016.4, OTTHUMP00000159556, ENST00000395655.8, OTTHUMT00000251350
    Conserved Domains (3) summary
    smart00952
    Location:453510
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:260326
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:344425
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

    Range
    45100100..45111747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    45143388..45155037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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