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PXYLP1 2-phosphoxylose phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 92370, updated on 22-Sep-2022

Summary

Official Symbol
PXYLP1provided by HGNC
Official Full Name
2-phosphoxylose phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:26303
See related
Ensembl:ENSG00000155893 MIM:619732; AllianceGenome:HGNC:26303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XYLP; ACPL2; HEL124
Summary
Enables phosphatase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of heparan sulfate proteoglycan biosynthetic process. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.1), placenta (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See PXYLP1 in Genome Data Viewer
Location:
3q23
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141231825..141294924)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (143979383..144042517)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (140950667..141013766)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 36 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 4 Neighboring gene ribosomal protein L31 pseudogene 21 Neighboring gene uncharacterized LOC124909441 Neighboring gene PHF5A pseudogene 7 Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene uncharacterized LOC124906291

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23751

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
2-phosphoxylose phosphatase 1
Names
acid phosphatase-like 2
acid phosphatase-like protein 2
epididymis luminal protein 124
xylosyl phosphatase
NP_001032249.1
NP_001269657.1
NP_689495.1
XP_005247960.1
XP_024309598.1
XP_047305165.1
XP_047305166.1
XP_047305167.1
XP_047305168.1
XP_047305169.1
XP_047305170.1
XP_047305171.1
XP_047305172.1
XP_047305173.1
XP_047305174.1
XP_047305175.1
XP_047305176.1
XP_047305177.1
XP_047305178.1
XP_047305179.1
XP_047305180.1
XP_047305181.1
XP_047305182.1
XP_047305183.1
XP_047305184.1
XP_047305185.1
XP_047305186.1
XP_047305187.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037172.3NP_001032249.1  2-phosphoxylose phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_001032249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC117383, AK074331, AL137529, BX647621, CX762355, DC409719
    Consensus CDS
    CCDS3116.1
    UniProtKB/Swiss-Prot
    Q8TE99, W0TR04
    UniProtKB/TrEMBL
    Q9NT50
    Related
    ENSP00000286353.4, ENST00000286353.9
    Conserved Domains (1) summary
    cl11399
    Location:87424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  2. NM_001282728.2NP_001269657.1  2-phosphoxylose phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_001269657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC117383, AK074331, AK297790, AL137529, BX647621, CX762355
    Consensus CDS
    CCDS63797.1
    UniProtKB/Swiss-Prot
    Q8TE99
    UniProtKB/TrEMBL
    B7Z4T2, Q9NT50
    Related
    ENSP00000422558.1, ENST00000502783.5
    Conserved Domains (1) summary
    cl11399
    Location:49386
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  3. NM_152282.5NP_689495.1  2-phosphoxylose phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_689495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC117383, AK074331, AK316121, AL137529, AY358460, BX647621, CX762355
    Consensus CDS
    CCDS3116.1
    UniProtKB/Swiss-Prot
    Q8TE99, W0TR04
    UniProtKB/TrEMBL
    B7Z3R9, Q9NT50
    Related
    ENSP00000376733.2, ENST00000393010.6
    Conserved Domains (1) summary
    cl11399
    Location:87424
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    141231825..141294924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449228.1XP_047305184.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  2. XM_047449230.1XP_047305186.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  3. XM_047449223.1XP_047305179.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  4. XM_047449229.1XP_047305185.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  5. XM_047449209.1XP_047305165.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  6. XM_047449214.1XP_047305170.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  7. XM_047449220.1XP_047305176.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  8. XM_047449219.1XP_047305175.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  9. XM_047449210.1XP_047305166.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  10. XM_047449215.1XP_047305171.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  11. XM_047449224.1XP_047305180.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  12. XM_047449216.1XP_047305172.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  13. XM_047449212.1XP_047305168.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  14. XM_047449225.1XP_047305181.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  15. XM_047449211.1XP_047305167.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  16. XM_047449222.1XP_047305178.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  17. XM_047449221.1XP_047305177.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  18. XM_047449226.1XP_047305182.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  19. XM_047449218.1XP_047305174.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  20. XM_047449227.1XP_047305183.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  21. XM_047449213.1XP_047305169.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  22. XM_047449217.1XP_047305173.1  2-phosphoxylose phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    W0TR04
  23. XM_024453830.2XP_024309598.1  2-phosphoxylose phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    E9PDB7
    Related
    ENSP00000422901.1, ENST00000508812.1
    Conserved Domains (1) summary
    cl11399
    Location:78415
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  24. XM_047449231.1XP_047305187.1  2-phosphoxylose phosphatase 1 isoform X4

    UniProtKB/TrEMBL
    B7Z4T2
  25. XM_005247903.5XP_005247960.1  2-phosphoxylose phosphatase 1 isoform X3

    See identical proteins and their annotated locations for XP_005247960.1

    UniProtKB/TrEMBL
    B7Z3R9
    Related
    ENSP00000426877.1, ENST00000504264.5
    Conserved Domains (1) summary
    cl11399
    Location:70407
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    143979383..144042517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)