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C1orf105 chromosome 1 open reading frame 105 [ Homo sapiens (human) ]

Gene ID: 92346, updated on 23-Nov-2021

Summary

Official Symbol
C1orf105provided by HGNC
Official Full Name
chromosome 1 open reading frame 105provided by HGNC
Primary source
HGNC:HGNC:29591
See related
Ensembl:ENSG00000180999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 3.1), heart (RPKM 0.4) and 1 other tissue See more
Orthologs
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Genomic context

See C1orf105 in Genome Data Viewer
Location:
1q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (172418560..172468829)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (172389825..172437969)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dynamin 3 Neighboring gene microRNA 199a-2 Neighboring gene DNM3 opposite strand/antisense RNA Neighboring gene uncharacterized LOC102724528 Neighboring gene RNA, U6 small nuclear 157, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10840 Neighboring gene Sharpr-MPRA regulatory region 5023 Neighboring gene Sharpr-MPRA regulatory region 3225 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
uncharacterized protein C1orf105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300760.1NP_001287689.1  uncharacterized protein C1orf105 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks multiple 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    Z97195
    Consensus CDS
    CCDS72983.1
    UniProtKB/TrEMBL
    Q5R3C7
    Related
    ENSP00000356698.4, ENST00000367725.4
    Conserved Domains (1) summary
    pfam15081
    Location:6172
    DUF4548; Domain of unknown function (DUF4548)
  2. NM_139240.4NP_640333.3  uncharacterized protein C1orf105 isoform 1

    See identical proteins and their annotated locations for NP_640333.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL035295, Z97195
    Consensus CDS
    CCDS1301.1
    UniProtKB/Swiss-Prot
    O95561
    Related
    ENSP00000356700.4, ENST00000367727.9
    Conserved Domains (1) summary
    pfam15081
    Location:17182
    DUF4548; Domain of unknown function (DUF4548)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    172418560..172468829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510152.2XP_011508454.1  uncharacterized protein C1orf105 isoform X1

    Conserved Domains (1) summary
    pfam15081
    Location:44209
    DUF4548; Domain of unknown function (DUF4548)
  2. XM_011510155.2XP_011508457.1  uncharacterized protein C1orf105 isoform X5

    Conserved Domains (1) summary
    pfam15081
    Location:44128
    DUF4548; Domain of unknown function (DUF4548)
  3. XM_011510153.2XP_011508455.1  uncharacterized protein C1orf105 isoform X3

    Conserved Domains (1) summary
    pfam15081
    Location:13178
    DUF4548; Domain of unknown function (DUF4548)
  4. XM_011510154.2XP_011508456.1  uncharacterized protein C1orf105 isoform X4

    See identical proteins and their annotated locations for XP_011508456.1

    Conserved Domains (1) summary
    pfam15081
    Location:1131
    DUF4548; Domain of unknown function (DUF4548)
  5. XM_011510156.2XP_011508458.1  uncharacterized protein C1orf105 isoform X6

    Conserved Domains (1) summary
    pfam15081
    Location:7123
    DUF4548; Domain of unknown function (DUF4548)
  6. XM_005245608.3XP_005245665.1  uncharacterized protein C1orf105 isoform X2

    Conserved Domains (1) summary
    pfam15081
    Location:17182
    DUF4548; Domain of unknown function (DUF4548)
  7. XM_005245610.4XP_005245667.1  uncharacterized protein C1orf105 isoform X4

    See identical proteins and their annotated locations for XP_005245667.1

    Conserved Domains (1) summary
    pfam15081
    Location:1131
    DUF4548; Domain of unknown function (DUF4548)
  8. XM_006711630.2XP_006711693.1  uncharacterized protein C1orf105 isoform X7

    Conserved Domains (1) summary
    pfam15081
    Location:8123
    DUF4548; Domain of unknown function (DUF4548)
  9. XM_017002808.1XP_016858297.1  uncharacterized protein C1orf105 isoform X4

    Conserved Domains (1) summary
    pfam15081
    Location:1131
    DUF4548; Domain of unknown function (DUF4548)
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