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METTL18 methyltransferase like 18 [ Homo sapiens (human) ]

Gene ID: 92342, updated on 24-Nov-2020

Summary

Official Symbol
METTL18provided by HGNC
Official Full Name
methyltransferase like 18provided by HGNC
Primary source
HGNC:HGNC:28793
See related
Ensembl:ENSG00000171806 MIM:615255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPM1; AsTP2; C1orf156
Expression
Ubiquitous expression in lymph node (RPKM 4.6), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See METTL18 in Genome Data Viewer
Location:
1q24.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (169792524..169794907, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169761670..169764088, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628 Neighboring gene chromosome 1 open reading frame 112 Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene SCY1 like pseudokinase 3 Neighboring gene VISTA enhancer hs1442 Neighboring gene kinesin associated protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-histidine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
peptidyl-histidine methylation, to form tele-methylhistidine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histidine protein methyltransferase 1 homolog
Names
arsenic-transactivated protein 2
methyltransferase-like protein 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320199.2NP_001307128.1  histidine protein methyltransferase 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC008679, BG614785, HY159746
    Consensus CDS
    CCDS1284.1
    UniProtKB/Swiss-Prot
    O95568
    UniProtKB/TrEMBL
    A0A024R8Y7
    Conserved Domains (1) summary
    cl17173
    Location:165324
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001320201.2NP_001307130.1  histidine protein methyltransferase 1 homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    BC008679
    Consensus CDS
    CCDS1284.1
    UniProtKB/Swiss-Prot
    O95568
    UniProtKB/TrEMBL
    A0A024R8Y7
    Related
    ENSP00000307077.2, ENST00000303469.6
    Conserved Domains (1) summary
    cl17173
    Location:165324
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_033418.4NP_219486.1  histidine protein methyltransferase 1 homolog

    See identical proteins and their annotated locations for NP_219486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    BC008679, HY159746
    Consensus CDS
    CCDS1284.1
    UniProtKB/Swiss-Prot
    O95568
    UniProtKB/TrEMBL
    A0A024R8Y7
    Related
    ENSP00000307975.4, ENST00000310392.5
    Conserved Domains (1) summary
    cl17173
    Location:165324
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    169792524..169794907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711627.3XP_006711690.1  histidine protein methyltransferase 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006711690.1

    UniProtKB/Swiss-Prot
    O95568
    UniProtKB/TrEMBL
    A0A024R8Y7
    Conserved Domains (1) summary
    cl17173
    Location:165324
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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