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SCGB3A1 secretoglobin family 3A member 1 [ Homo sapiens (human) ]

Gene ID: 92304, updated on 5-Jul-2025
Official Symbol
SCGB3A1provided by HGNC
Official Full Name
secretoglobin family 3A member 1provided by HGNC
Primary source
HGNC:HGNC:18384
See related
Ensembl:ENSG00000161055 MIM:606500; AllianceGenome:HGNC:18384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIN1; HIN-1; LU105; UGRP2; PnSP-2
Summary
Predicted to enable cytokine activity. Predicted to be involved in positive regulation of myoblast fusion. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in lung (RPKM 109.6), salivary gland (RPKM 64.7) and 1 other tissue See more
Orthologs
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See SCGB3A1 in Genome Data Viewer
Location:
5q35.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180590105..180591499, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181145993..181147387, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180017105..180018499, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102725231 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:179894063-179895262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179901825-179902356 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:179912532-179913731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16769 Neighboring gene CCR4-NOT transcription complex subunit 6 Neighboring gene NANOG hESC enhancer GRCh37_chr5:179954464-179954965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179958359-179959013 Neighboring gene proteolipid protein 2 (colonic epithelium-enriched) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23769 Neighboring gene Sharpr-MPRA regulatory region 4663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180016691-180017360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180017361-180018030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180018031-180018700 Neighboring gene uncharacterized LOC124901154 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180023713-180023884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180029578-180030078 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:180046831-180048030 Neighboring gene fms related receptor tyrosine kinase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180059019-180059648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180059649-180060278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180066955-180067601 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180069214-180069370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180072499-180073164

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Clone Names

  • MGC87867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
secretoglobin family 3A member 1
Names
cytokine HIN-1
cytokine high in normal-1
high in normal 1
pneumo secretory protein 2
uteroglobin-related protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052863.3NP_443095.2  secretoglobin family 3A member 1 precursor

    See identical proteins and their annotated locations for NP_443095.2

    Status: VALIDATED

    Source sequence(s)
    AC122714, AY359064
    Consensus CDS
    CCDS4456.1
    UniProtKB/Swiss-Prot
    Q96PL0, Q96QR1
    Related
    ENSP00000292641.3, ENST00000292641.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180590105..180591499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181145993..181147387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)