U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM132C transmembrane protein 132C [ Homo sapiens (human) ]

Gene ID: 92293, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM132Cprovided by HGNC
Official Full Name
transmembrane protein 132Cprovided by HGNC
Primary source
HGNC:HGNC:25436
See related
Ensembl:ENSG00000181234 AllianceGenome:HGNC:25436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R152
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 20.4), endometrium (RPKM 2.3) and 6 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TMEM132C in Genome Data Viewer
Location:
12q24.32-q24.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (128267170..128707911)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (128297066..128738704)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (128751715..129192456)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2368 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:128642903-128643556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:128674654-128675653 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:128743759-128744260 Neighboring gene uncharacterized LOC107987176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:128750861-128751382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:128751918-128752756 Neighboring gene microRNA 3612 Neighboring gene NANOG hESC enhancer GRCh37_chr12:128866078-128866579 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:128867427-128868398 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:128868399-128869369 Neighboring gene uncharacterized LOC124903115 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:128942780-128943732 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:128943733-128944685 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:129028409-129028584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5087 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:129141297-129142496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:129148562-129149148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25284 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129192543-129193044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129193045-129193544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7327 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:129212543-129213042 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:129238411-129239610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129271367-129271867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129276413-129276913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7331 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:129281709-129282908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129286977-129287478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:129287479-129287978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7339 Neighboring gene uncharacterized LOC124903083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7341 Neighboring gene uncharacterized LOC124903089 Neighboring gene solute carrier family 15 member 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A genome-wide association study of attempted suicide. Willour VL, et al. Mol Psychiatry, 2012 Apr. PMID 21423239, Free PMC Article
  2. TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Sanchez-Pulido L, et al. Bioinformatics, 2018 Mar 1. PMID 29088312, Free PMC Article
  3. Genome-wide association study in Han Chinese identifies three novel loci for human height. Hao Y, et al. Hum Genet, 2013 Jun. PMID 23456168
  4. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Chung S, et al. Breast Cancer Res, 2013. PMID 24025145, Free PMC Article
  5. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of attempted suicide.
EBI GWAS Catalog
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
EBI GWAS Catalog
Genome-wide association study in Han Chinese identifies three novel loci for human height.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 132C (TMEM132C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp761O2018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 132C
Names
protein phosphatase 1, regulatory subunit 152

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136103.3 → NP_001129575.2  transmembrane protein 132C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129575.2

    Status: VALIDATED

    Source sequence(s)
    AC023595, AC061709, AC090424, AC107020
    Consensus CDS
    CCDS45009.2
    UniProtKB/Swiss-Prot
    Q69YX8, Q8N3T6
    Related
    ENSP00000410852.2, ENST00000435159.3
    Conserved Domains (3) summary
    pfam15705
    Location:51 → 181
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:893 → 979
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:438 → 780
    TMEM132; Transmembrane protein family 132

  2. NM_001387058.1 → NP_001373987.1  transmembrane protein 132C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023595, AC061709, AC090424, AC107020
    Conserved Domains (3) summary
    pfam15705
    Location:31 → 161
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:873 → 957
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:418 → 761
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    128267170..128707911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429886.1 → XP_047285842.1  transmembrane protein 132C isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    128297066..128738704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373842.1 → XP_054229817.1  transmembrane protein 132C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3T6.3 GenPept UniProtKB/Swiss-Prot:Q8N3T6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous