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TMEM132C transmembrane protein 132C [ Homo sapiens (human) ]

Gene ID: 92293, updated on 23-Nov-2021

Summary

Official Symbol
TMEM132Cprovided by HGNC
Official Full Name
transmembrane protein 132Cprovided by HGNC
Primary source
HGNC:HGNC:25436
See related
Ensembl:ENSG00000181234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R152
Expression
Biased expression in fat (RPKM 20.4), endometrium (RPKM 2.3) and 6 other tissues See more
Orthologs
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Genomic context

See TMEM132C in Genome Data Viewer
Location:
12q24.32-q24.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (128267170..128707915)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (128751715..129192456)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2368 Neighboring gene uncharacterized LOC107987176 Neighboring gene microRNA 3612 Neighboring gene Sharpr-MPRA regulatory region 7648 Neighboring gene uncharacterized LOC100128276 Neighboring gene solute carrier family 15 member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of attempted suicide.
GeneReviews: Not available
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
GeneReviews: Not available
Genome-wide association study in Han Chinese identifies three novel loci for human height.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 132C (TMEM132C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761O2018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 132C
Names
protein phosphatase 1, regulatory subunit 152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136103.3NP_001129575.2  transmembrane protein 132C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129575.2

    Status: VALIDATED

    Source sequence(s)
    AC023595, AC061709, AC090424, AC107020
    Consensus CDS
    CCDS45009.2
    UniProtKB/Swiss-Prot
    Q8N3T6
    Related
    ENSP00000410852.2, ENST00000435159.3
    Conserved Domains (3) summary
    pfam15705
    Location:51181
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:893979
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:438780
    TMEM132; Transmembrane protein family 132
  2. NM_001387058.1NP_001373987.1  transmembrane protein 132C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023595, AC061709, AC090424, AC107020
    Conserved Domains (3) summary
    pfam15705
    Location:31161
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:873957
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:418761
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    128267170..128707915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001748922.1 RNA Sequence

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