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DLGAP1 DLG associated protein 1 [ Homo sapiens (human) ]

Gene ID: 9229, updated on 17-May-2023

Summary

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Official Symbol
DLGAP1provided by HGNC
Official Full Name
DLG associated protein 1provided by HGNC
Primary source
HGNC:HGNC:2905
See related
Ensembl:ENSG00000170579 MIM:605445; AllianceGenome:HGNC:2905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA
Summary
Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be part of postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See DLGAP1 in Genome Data Viewer
Location:
18p11.31
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (3496032..4455307, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (3655540..4615578, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (3496030..4455307, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371965 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:3466751-3467438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:3469136-3469926 Neighboring gene Sharpr-MPRA regulatory region 485 Neighboring gene gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNA Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:3554877-3555427 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3575965-3576466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:3576467-3576966 Neighboring gene zinc finger protein 592 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3595284-3596254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3596255-3597226 Neighboring gene Sharpr-MPRA regulatory region 8249 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3601961-3602755 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3603326-3604525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3610951-3611462 Neighboring gene DLGAP1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:3623835-3625034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:3625199-3625770 Neighboring gene RNA, 7SL, cytoplasmic 39, pseudogene Neighboring gene DLGAP1 antisense RNA 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:3652584-3653783 Neighboring gene uncharacterized LOC105371967 Neighboring gene Sharpr-MPRA regulatory region 6172 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr18:3821582-3822083 Neighboring gene uncharacterized LOC124904238 Neighboring gene DLGAP1 antisense RNA 3 Neighboring gene RNA, U6 small nuclear 831, pseudogene Neighboring gene microRNA 6718 Neighboring gene DLGAP1 antisense RNA 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:4017491-4018172 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 66 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4118324-4118910 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4119078-4119849 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4117736-4118323 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4124501-4125480 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:4125481-4126460 Neighboring gene uncharacterized LOC124904239 Neighboring gene Sharpr-MPRA regulatory region 11006 Neighboring gene NANOG hESC enhancer GRCh37_chr18:4195745-4196246 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:4233399-4234316 Neighboring gene DLGAP1 antisense RNA 5 Neighboring gene Sharpr-MPRA regulatory region 437 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:4477591-4478233 Neighboring gene elongin C pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer. Liang X, et al. Mol Biol Rep, 2022 May. PMID 35449318
  2. A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. Takahashi Y, et al. Sci Rep, 2021 Sep 30. PMID 34593835, Free PMC Article
  3. DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder. Fan Z, et al. Brain Behav, 2018 Feb. PMID 29484270, Free PMC Article
  4. Genome-Wide Association Study of HIV-Related Lipoatrophy in Thai Patients: Association of a DLGAP1 Polymorphism with Fat Loss. Uttayamakul S, et al. AIDS Res Hum Retroviruses, 2015 Aug. PMID 25950743, Free PMC Article
  5. Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia. Li JM, et al. Psychiatry Res, 2013 Jan 30. PMID 22940546

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer.
    Title: DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer.
  2. N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop.
    Title: N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop.
  3. A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population.
    Title: A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population.
  4. LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
    Title: LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
  5. The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function.
    Title: Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level.
  6. We demonstrated that miR-148a was upregulated, DLGAP1 was downregulated in glioblastoma, and DLGAP1 was a direct target of miR-148a.
    Title: The role of microRNA-148a and downstream DLGAP1 on the molecular regulation and tumor progression on human glioblastoma.
  7. Study presents evidence that the expression of GKAP modulates the activity of the glutamate-to-NMDAR signaling pathway and promotes invasiveness in mouse neuroendocrine (PanNET) and in both mouse and human ductal (PDAC) cancer cell lines.
    Title: GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth.
  8. Association of two significant SNPs of DLGAP1 with cognitive flexibility in Attention Deficit Hyperactivity Disorder was observed.
    Title: DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.
  9. This study revealed a significant variant (rs12455524) within the gene DLGAP1 for Recurrent major depression.
    Title: Recurrent major depression and right hippocampal volume: A bivariate linkage and association study.
  10. These results strongly suggested involvement of the DLGAP1 gene product in the development of HIV-related lipoatrophy in Thai HIV patients.
    Title: Genome-Wide Association Study of HIV-Related Lipoatrophy in Thai Patients: Association of a DLGAP1 Polymorphism with Fat Loss.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of discs, large (Drosophila) homolog-associated protein 1 (DLGAP1; LOC284214) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38442, MGC88156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
disks large-associated protein 1
Names
PSD-95/SAP90 binding protein 1
SAP90/PSD-95-associated protein 1
discs large homolog associated protein 1
guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003809.3 → NP_001003809.1  disks large-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001003809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294747, AK316099, AP002472, BC136453, CR743383
    Consensus CDS
    CCDS42406.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383011.2, ENST00000400147.6
    Conserved Domains (1) summary
    pfam03359
    Location:343 → 675
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_001242761.2 → NP_001229690.1  disks large-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001229690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (3) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK316099, AP005241, AP005403, U67988
    Consensus CDS
    CCDS56053.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000463864.1, ENST00000581527.5
    Conserved Domains (1) summary
    pfam03359
    Location:645 → 911
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. NM_001242762.2 → NP_001229691.1  disks large-associated protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001229691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000277, AK095761, AK294717, AP002472, CR743383
    Consensus CDS
    CCDS56052.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000437817.1, ENST00000534970.5
    Conserved Domains (1) summary
    pfam03359
    Location:329 → 661
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. NM_001242763.2 → NP_001229692.1  disks large-associated protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001229692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294717, AK294777, AP002472, AP002478, CR743383
    Consensus CDS
    CCDS74191.1
    UniProtKB/Swiss-Prot
    O14490
    UniProtKB/TrEMBL
    A0A0A0MTP4, B7Z2J5
    Related
    ENSP00000445973.2, ENST00000515196.6
    Conserved Domains (1) summary
    pfam03359
    Location:367 → 699
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  5. NM_001242764.2 → NP_001229693.1  disks large-associated protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001229693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK299880, AP002472, AP005204, BC136453, CR743383
    Consensus CDS
    CCDS56051.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383019.1, ENST00000400155.5
    Conserved Domains (1) summary
    pfam03359
    Location:351 → 683
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  6. NM_001242765.2 → NP_001229694.1  disks large-associated protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001229694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK294747, U67988
    Consensus CDS
    CCDS56049.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383010.2, ENST00000400145.6
    Conserved Domains (1) summary
    pfam03359
    Location:343 → 609
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  7. NM_001242766.2 → NP_001229695.1  disks large-associated protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001229695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (8) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294747, AP002472, BC136453, CR743383
    Consensus CDS
    CCDS56050.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000446312.1, ENST00000539435.5
    Conserved Domains (1) summary
    pfam03359
    Location:353 → 685
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  8. NM_001308390.2 → NP_001295319.1  disks large-associated protein 1 isoform 9

    See identical proteins and their annotated locations for NP_001295319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AP002472, AP002478, AP005204
    Consensus CDS
    CCDS77146.1
    UniProtKB/TrEMBL
    A8MXQ8
    Related
    ENSP00000383014.3, ENST00000400150.7
    Conserved Domains (1) summary
    pfam03359
    Location:361 → 693
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  9. NM_001398525.1 → NP_001385454.1  disks large-associated protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
    Conserved Domains (1) summary
    pfam03359
    Location:655 → 987
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  10. NM_001398526.1 → NP_001385455.1  disks large-associated protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
    Conserved Domains (1) summary
    pfam03359
    Location:655 → 987
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  11. NM_001398527.1 → NP_001385456.1  disks large-associated protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005130, AP005204, AP005241, AP005403
    Consensus CDS
    CCDS11836.1
    UniProtKB/Swiss-Prot
    P78335
    Conserved Domains (1) summary
    pfam03359
    Location:645 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  12. NM_001398528.1 → NP_001385457.1  disks large-associated protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005130, AP005204, AP005241, AP005403

  13. NM_001398530.1 → NP_001385459.1  disks large-associated protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  14. NM_001398531.1 → NP_001385460.1  disks large-associated protein 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Conserved Domains (1) summary
    pfam03359
    Location:399 → 731
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  15. NM_001398532.1 → NP_001385461.1  disks large-associated protein 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Related
    ENSP00000383013.3, ENST00000400149.7
    Conserved Domains (1) summary
    pfam03359
    Location:363 → 695
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  16. NM_001398533.1 → NP_001385462.1  disks large-associated protein 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Conserved Domains (1) summary
    pfam03359
    Location:357 → 689
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  17. NM_001398534.1 → NP_001385463.1  disks large-associated protein 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Conserved Domains (1) summary
    pfam03359
    Location:353 → 685
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  18. NM_001398535.1 → NP_001385464.1  disks large-associated protein 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  19. NM_001398536.1 → NP_001385465.1  disks large-associated protein 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  20. NM_001398537.1 → NP_001385466.1  disks large-associated protein 1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Related
    ENSP00000516677.1, ENST00000706956.1

  21. NM_001398539.1 → NP_001385468.1  disks large-associated protein 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  22. NM_001398540.1 → NP_001385469.1  disks large-associated protein 1 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  23. NM_001398541.1 → NP_001385470.1  disks large-associated protein 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  24. NM_001398542.1 → NP_001385471.1  disks large-associated protein 1 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  25. NM_001398543.1 → NP_001385472.1  disks large-associated protein 1 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Conserved Domains (1) summary
    pfam03359
    Location:353 → 619
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  26. NM_001398544.1 → NP_001385473.1  disks large-associated protein 1 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  27. NM_001398545.1 → NP_001385474.1  disks large-associated protein 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204
    Conserved Domains (1) summary
    pfam03359
    Location:351 → 617
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  28. NM_001398546.1 → NP_001385475.1  disks large-associated protein 1 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AP002472, AP002478, AP005204

  29. NM_004746.4 → NP_004737.2  disks large-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004737.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
    Source sequence(s)
    AK095761, AK316099, AP002472, AP005241, AP005403, BC136453, CR743383
    Consensus CDS
    CCDS11836.1
    UniProtKB/Swiss-Prot
    O14490, P78335
    Related
    ENSP00000316377.3, ENST00000315677.8
    Conserved Domains (1) summary
    pfam03359
    Location:645 → 977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    3496032..4455307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437933.1 → XP_047293889.1  disks large-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P78335

  2. XM_024451288.2 → XP_024307056.1  disks large-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03359
    Location:655 → 987
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. XM_047437934.1 → XP_047293890.1  disks large-associated protein 1 isoform X3

  4. XM_017026080.2 → XP_016881569.1  disks large-associated protein 1 isoform X4

  5. XM_047437936.1 → XP_047293892.1  disks large-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    Q6IS01

  6. XM_011525771.4 → XP_011524073.1  disks large-associated protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011524073.1

    UniProtKB/TrEMBL
    Q6IS01
    Related
    ENSP00000491005.1, ENST00000639615.1

  7. XM_047437935.1 → XP_047293891.1  disks large-associated protein 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    3655540..4615578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319361.1 → XP_054175336.1  disks large-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P78335

  2. XM_054319360.1 → XP_054175335.1  disks large-associated protein 1 isoform X1

  3. XM_054319362.1 → XP_054175337.1  disks large-associated protein 1 isoform X3

  4. XM_054319363.1 → XP_054175338.1  disks large-associated protein 1 isoform X4

  5. XM_054319366.1 → XP_054175341.1  disks large-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    Q6IS01

  6. XM_054319365.1 → XP_054175340.1  disks large-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    Q6IS01

  7. XM_054319364.1 → XP_054175339.1  disks large-associated protein 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14490.1 GenPept UniProtKB/Swiss-Prot:O14490

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