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ZNF461 zinc finger protein 461 [ Homo sapiens (human) ]

Gene ID: 92283, updated on 11-Jun-2021

Summary

Official Symbol
ZNF461provided by HGNC
Official Full Name
zinc finger protein 461provided by HGNC
Primary source
HGNC:HGNC:21629
See related
Ensembl:ENSG00000197808 MIM:608640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIOT1; HZF28; GIOT-1
Expression
Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF461 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36636618..36666837, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37127520..37157739, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 529 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 567 Neighboring gene ZNF567 divergent transcript Neighboring gene zinc finger protein 850

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 461
Names
gonadotropin-inducible ovary transcription repressor 1
zinc finger protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297623.3NP_001284552.1  zinc finger protein 461 isoform 2

    See identical proteins and their annotated locations for NP_001284552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AB021641, AC074138, AK299370
    Consensus CDS
    CCDS74348.1
    UniProtKB/Swiss-Prot
    Q8TAF7
    UniProtKB/TrEMBL
    B4DRP8
    Related
    ENSP00000353515.4, ENST00000360357.8
    Conserved Domains (4) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:289492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:264289
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001322821.2NP_001309750.1  zinc finger protein 461 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (5) summary
    smart00349
    Location:260
    KRAB; krueppel associated box
    COG5048
    Location:306509
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:239
    KRAB; KRAB box
    pfam13465
    Location:449472
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001322823.2NP_001309752.1  zinc finger protein 461 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074138, BX649031, DC339675
    Conserved Domains (4) summary
    COG5048
    Location:281484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:256281
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1535
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  4. NM_001322825.2NP_001309754.1  zinc finger protein 461 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:281484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:256281
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1535
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  5. NM_001322826.2NP_001309755.1  zinc finger protein 461 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:258461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233258
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1535
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. NM_001322827.2NP_001309756.1  zinc finger protein 461 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC074138
    Conserved Domains (4) summary
    COG5048
    Location:258461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:389409
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:233258
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:1535
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  7. NM_001322828.2NP_001309757.1  zinc finger protein 461 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC074138, DC308305, DC339675
    Conserved Domains (3) summary
    COG5048
    Location:224427
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:199224
    zf-H2C2_2; Zinc-finger double domain
  8. NM_153257.5NP_694989.2  zinc finger protein 461 isoform 1

    See identical proteins and their annotated locations for NP_694989.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB021641, AC074138, AK299370, AY329493
    Consensus CDS
    CCDS54257.1
    UniProtKB/Swiss-Prot
    Q8TAF7
    UniProtKB/TrEMBL
    B4DRP8
    Related
    ENSP00000467931.1, ENST00000588268.6
    Conserved Domains (4) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:312515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:287312
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36636618..36666837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027470.1XP_016882959.1  zinc finger protein 461 isoform X1

  2. XM_011527486.2XP_011525788.1  zinc finger protein 461 isoform X2

    See identical proteins and their annotated locations for XP_011525788.1

    UniProtKB/Swiss-Prot
    Q8TAF7
    Conserved Domains (2) summary
    COG5048
    Location:200388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316336
    ZF_C2H2; C2H2 Zn finger [structural motif]
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