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PF3D7_0831700 heat shock protein 70 [ Plasmodium falciparum 3D7 ]

Gene ID: 9221911, updated on 12-Sep-2024
Gene symbol
PF3D7_0831700
Gene description
heat shock protein 70
Locus tag
PF3D7_0831700
See related
PlasmoDB:PF3D7_0831700; VEuPathDB:PF3D7_0831700
Gene type
protein coding
RNA name
heat shock protein 70
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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See PF3D7_0831700 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
1
Sequence:
Chromosome: 8; NC_004329.3 (1365467..1367506, complement)

Chromosome 8 - NC_004329.3Genomic Context describing neighboring genes Neighboring gene Plasmodium exported protein (PHIST), unknown function Neighboring gene cytoadherence linked asexual protein 8 Neighboring gene pseudo Neighboring gene histidine-rich protein II

Genomic Sequence:
NC_004329.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif. Mabate B, et al. Proteins, 2018 Nov. PMID 30183110, Free PMC Article
  2. The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites. Charnaud SC, et al. PLoS One, 2017. PMID 28732045, Free PMC Article
  3. Trafficking of the exported P. falciparum chaperone PfHsp70x. Rhiel M, et al. Sci Rep, 2016 Nov 8. PMID 27824087, Free PMC Article
  4. Plasmodium falciparum Hsp70-x: a heat shock protein at the host-parasite interface. Hatherley R, et al. J Biomol Struct Dyn, 2014. PMID 24028577
  5. Identification of an exported heat shock protein 70 in Plasmodium falciparum. Grover M, et al. Parasite, 2013. PMID 23340228, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings suggest that the EEVN residues of Plasmodium falciparum heat shock protein 70 are important for its ATPase activity and chaperone function.
    Title: Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif.
  2. Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein
    Title: Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.
  3. The host-pathogen interaction within the infected erythrocyte is more complex than previously thought, and is driven not only by parasite co-chaperones, but also by the parasite-encoded chaperone Hsp70-x itself.
    Title: Plasmodium falciparum-encoded exported hsp70/hsp40 chaperone/co-chaperone complexes within the host erythrocyte.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables heat shock protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adhesion of symbiont to microvasculature IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Maurer's cleft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular vesicle HDA PubMed 
located_in host cell cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in host cell cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
heat shock protein 70

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004329.3 Reference assembly

    Range
    1365467..1367506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024473179.1 → XP_024329068.1  heat shock protein 70 [Plasmodium falciparum 3D7]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V7S5, A0A024W953, A0A024WR76, A0A024XAL9, A0A0L1IFC4, K7NTP5, W4IK96, W4ISL5, W7FGF2, W7FK92, W7K165, W7K618
    Conserved Domains (1) summary
    PTZ00009
    Location:31 → 679
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein
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Gene LinkOut

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