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PF3D7_0417200 bifunctional dihydrofolate reductase-thymidylate synthase [ Plasmodium falciparum 3D7 ]

Gene ID: 9221804, updated on 15-Feb-2026
Gene symbol
PF3D7_0417200
Gene description
bifunctional dihydrofolate reductase-thymidylate synthase
Locus tag
PF3D7_0417200
See related
PlasmoDB:PF3D7_0417200; VEuPathDB:PF3D7_0417200
Gene type
protein coding
RNA name
bifunctional dihydrofolate reductase-thymidylate synthase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Try the new Transcripts and proteins table
See PF3D7_0417200 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_004318.2 (748088..749914)

Chromosome 4 - NC_004318.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene mRNA-binding protein PUF2 Neighboring gene LETM1-like protein, putative Neighboring gene conserved Plasmodium protein, unknown function

Genomic Sequence:
NC_004318.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Antimalarial effect of cell penetrating peptides derived from the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Chaianantakul N, et al. Peptides, 2020 Sep. PMID 32673701
  2. Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities. Kamchonwongpaisan S, et al. Eur J Med Chem, 2020 Jun 1. PMID 32294614
  3. Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan. Bilsland E, et al. Sci Rep, 2018 Jan 18. PMID 29348637, Free PMC Article
  4. Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Chaianantakul N, et al. Malar J, 2013 Mar 12. PMID 23497065, Free PMC Article
  5. Insights into antifolate resistance from malarial DHFR-TS structures. Yuvaniyama J, et al. Nat Struct Biol, 2003 May. PMID 12704428

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Antimalarial effect of cell penetrating peptides derived from the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
    Title: Antimalarial effect of cell penetrating peptides derived from the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
  2. Polymorphism in dihydrofolate reductase and dihydropteroate synthetase genes after five years of artemisinin combination therapy (ACT) implementation in urban India has been reported.
    Title: Polymorphisms in pfdhfr and pfdhps genes after five years of artemisinin combination therapy (ACT) implementation from urban Kolkata, India.
  3. Plasmodium vivax and P. falciparum dhfr and dhps genes were sequenced to detect nucleotide polymorphisms in malaria patients before introduction of chloroquine and sulphadoxine-pyrimethamine.
    Title: Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy.
  4. Report on the mutational analysis of pfdhfr and pfdhps in single Plasmodium falciparum infection isolates from the interior division of Sabah, Malaysian Borneo.
    Title: Mutational analysis of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in the interior division of Sabah, Malaysia.
  5. This study demonstrated the interactions between the pfDHFR and pfTS domains of the bifunctional pfDHFR-TS, and revealed that the junctional region linking the two protein domains is essential for the expression of catalytically active pfTS domain.
    Title: Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
  6. the TS subunit interface between Plasmodium species is sufficiently conserved to allow formation of fully active cross-species heterodimer
    Title: Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
bifunctional dihydrofolate reductase-thymidylate synthase
XP_001351479.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004318.2 Reference assembly

    Range
    748088..749914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351443.1 → XP_001351479.1  bifunctional dihydrofolate reductase-thymidylate synthase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351479.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VW45, A0A024XEY0, A0A0L1I5F1, A7UD79, A7UD81, Q8I1R6, W4J4Y7, W7GBL9, W7K8T7
    Conserved Domains (1) summary
    PTZ00164
    Location:2 → 608
    PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional
Nucleotide Protein
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