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NOLC1 nucleolar and coiled-body phosphoprotein 1 [ Homo sapiens (human) ]

Gene ID: 9221, updated on 21-Jun-2020

Summary

Official Symbol
NOLC1provided by HGNC
Official Full Name
nucleolar and coiled-body phosphoprotein 1provided by HGNC
Primary source
HGNC:HGNC:15608
See related
Ensembl:ENSG00000166197 MIM:602394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P130; Srp40; NOPP130; NOPP140; NS5ATP13
Expression
Ubiquitous expression in brain (RPKM 23.0), thyroid (RPKM 22.8) and 25 other tissues See more
Orthologs

Genomic context

See NOLC1 in Genome Data Viewer
Location:
10q24.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102152176..102163871)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103911933..103923627)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene LIM domain binding 1 Neighboring gene PPARG related coactivator 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired like homeodomain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA is identified to have a physical interaction with nucleolar and coiled-body phosphoprotein 1 (NOLC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase I core binding IDA
Inferred from Direct Assay
more info
PubMed 
box C/D snoRNA binding IEA
Inferred from Electronic Annotation
more info
 
box C/D snoRNP complex binding IEA
Inferred from Electronic Annotation
more info
 
box H/ACA snoRNA binding IEA
Inferred from Electronic Annotation
more info
 
box H/ACA snoRNP complex binding IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
box H/ACA snoRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural crest formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolus organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rRNA processing TAS
Traceable Author Statement
more info
PubMed 
regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
box C/D snoRNP complex IEA
Inferred from Electronic Annotation
more info
 
box H/ACA snoRNP complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar and coiled-body phosphoprotein 1
Names
140 kDa nucleolar phosphoprotein
HCV NS5A trans-regulated protein 13
HCV NS5A-transactivated protein 13
hepatitis C virus NS5A-transactivated protein 13
nucleolar 130 kDa protein
nucleolar and coiled-body phosphprotein 1
nucleolar phosphoprotein p130
nucleolar protein p130

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284388.1NP_001271317.1  nucleolar and coiled-body phosphoprotein 1 isoform 1

    See identical proteins and their annotated locations for NP_001271317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK314363, AL520884, CF145090, D21262, DA588285
    Consensus CDS
    CCDS65926.1
    UniProtKB/Swiss-Prot
    Q14978
    UniProtKB/TrEMBL
    B2RAU8
    Related
    ENSP00000385410.1, ENST00000405356.5
    Conserved Domains (1) summary
    pfam05022
    Location:634700
    SRP40_C; SRP40, C-terminal domain
  2. NM_001284389.2NP_001271318.1  nucleolar and coiled-body phosphoprotein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL520884, BC001883, D21262, DA588285
    Consensus CDS
    CCDS65925.1
    UniProtKB/Swiss-Prot
    Q14978
    Related
    ENSP00000475080.1, ENST00000488254.6
    Conserved Domains (1) summary
    pfam05022
    Location:625691
    SRP40_C; SRP40, C-terminal domain
  3. NM_004741.5NP_004732.2  nucleolar and coiled-body phosphoprotein 1 isoform 2

    See identical proteins and their annotated locations for NP_004732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK314363, AL520884, BC006769
    Consensus CDS
    CCDS7530.1
    UniProtKB/Swiss-Prot
    Q14978
    UniProtKB/TrEMBL
    B2RAU8, Q96J17
    Related
    ENSP00000474710.1, ENST00000605788.5
    Conserved Domains (1) summary
    pfam05022
    Location:624690
    SRP40_C; SRP40, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102152176..102163871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270273.2XP_005270330.1  nucleolar and coiled-body phosphoprotein 1 isoform X1

    Conserved Domains (1) summary
    pfam05022
    Location:635701
    SRP40_C; SRP40, C-terminal domain
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