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DAPL1 death associated protein like 1 [ Homo sapiens (human) ]

Gene ID: 92196, updated on 5-Aug-2022

Summary

Official Symbol
DAPL1provided by HGNC
Official Full Name
death associated protein like 1provided by HGNC
Primary source
HGNC:HGNC:21490
See related
Ensembl:ENSG00000163331 AllianceGenome:HGNC:21490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable death domain binding activity. Predicted to be involved in apoptotic signaling pathway; cellular response to amino acid starvation; and negative regulation of autophagy. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 59.4), skin (RPKM 46.5) and 3 other tissues See more
Orthologs
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Genomic context

See DAPL1 in Genome Data Viewer
Location:
2q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (158795317..158815990)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (159251305..159278068)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (159651829..159672502)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene plakophilin 4 Neighboring gene Sharpr-MPRA regulatory region 6347 Neighboring gene PKP4 antisense RNA 1 Neighboring gene uncharacterized LOC124907901 Neighboring gene olfactory receptor family 7 subfamily E member 89 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 28 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables death domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
death-associated protein-like 1
Names
early epithelial differentiation-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017920.3NP_001017920.2  death-associated protein-like 1

    See identical proteins and their annotated locations for NP_001017920.2

    Status: VALIDATED

    Source sequence(s)
    AC079877, AF086541, AY324399, BC127683, CD675155
    Consensus CDS
    CCDS33307.1
    UniProtKB/Swiss-Prot
    A0PJW8, B9EIK6
    UniProtKB/TrEMBL
    M1E9T5
    Related
    ENSP00000309538.4, ENST00000309950.8
    Conserved Domains (1) summary
    pfam15228
    Location:13106
    DAP; Death-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    158795317..158815990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    159251305..159278068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)