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MTG1 mitochondrial ribosome associated GTPase 1 [ Homo sapiens (human) ]

Gene ID: 92170, updated on 5-Aug-2022

Summary

Official Symbol
MTG1provided by HGNC
Official Full Name
mitochondrial ribosome associated GTPase 1provided by HGNC
Primary source
HGNC:HGNC:32159
See related
Ensembl:ENSG00000148824 AllianceGenome:HGNC:32159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTP; GTPBP7
Summary
Enables GTPase activity. Involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrial inner membrane and mitochondrial ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 19.8), duodenum (RPKM 18.8) and 25 other tissues See more
Orthologs
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Genomic context

See MTG1 in Genome Data Viewer
Location:
10q26.3
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133394157..133422520)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134349129..134377446)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135207661..135236024)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902563 Neighboring gene polyamine oxidase Neighboring gene Sharpr-MPRA regulatory region 11835 Neighboring gene uncharacterized LOC124902564 Neighboring gene shadow of prion protein Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PAOX

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial ribosome-associated GTPase 1
Names
GTP-binding protein 7 (putative)
mitochondrial GTPase 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138384.4NP_612393.2  mitochondrial ribosome-associated GTPase 1

    See identical proteins and their annotated locations for NP_612393.2

    Status: VALIDATED

    Source sequence(s)
    AI344070, AL161645, AL360181
    Consensus CDS
    CCDS31320.1
    UniProtKB/Swiss-Prot
    Q9BT17, Q9BVU8
    Related
    ENSP00000323047.6, ENST00000317502.11
    Conserved Domains (1) summary
    cd01856
    Location:30207
    YlqF; Circularly permuted YlqF GTPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133394157..133422520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134349129..134377446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)