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MTSS2 MTSS I-BAR domain containing 2 [ Homo sapiens (human) ]

Gene ID: 92154, updated on 5-Jan-2022

Summary

Official Symbol
MTSS2provided by HGNC
Official Full Name
MTSS I-BAR domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25094
See related
Ensembl:ENSG00000132613 MIM:616951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABBA; ABBA1; ABBA-1; MTSS1L
Summary
Enables GTPase activator activity and small GTPase binding activity. Involved in activation of GTPase activity and cellular response to platelet-derived growth factor stimulus. Located in ruffle membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in brain (RPKM 49.9), endometrium (RPKM 14.9) and 19 other tissues See more
Orthologs
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Genomic context

See MTSS2 in Genome Data Viewer
Location:
16q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70661204..70686053, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70695107..70719956, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene interleukin 34 Neighboring gene VAC14 component of PIKFYVE complex Neighboring gene Sharpr-MPRA regulatory region 12359 Neighboring gene VAC14 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lamellipodium organization IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in intrinsic component of the cytoplasmic side of the plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein MTSS 2
Names
MTSS1-like protein
MTSS1L, I-BAR domain containing
actin-bundling with BAIAP2 homology protein 1
metastasis suppressor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051360.1 RefSeqGene

    Range
    4999..29848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138383.3NP_612392.1  protein MTSS 2

    See identical proteins and their annotated locations for NP_612392.1

    Status: VALIDATED

    Source sequence(s)
    AB115770, AC020763, BU859607
    Consensus CDS
    CCDS32476.1
    UniProtKB/Swiss-Prot
    Q765P7
    Related
    ENSP00000341171.6, ENST00000338779.11
    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70661204..70686053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256236.5XP_005256293.3  protein MTSS 2 isoform X6

    Conserved Domains (1) summary
    cd07643
    Location:6236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  2. XM_011523454.3XP_011521756.3  protein MTSS 2 isoform X2

    Conserved Domains (2) summary
    cd07643
    Location:6236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam05109
    Location:298651
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  3. XM_017023881.2XP_016879370.2  protein MTSS 2 isoform X5

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  4. XM_017023879.2XP_016879368.2  protein MTSS 2 isoform X3

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  5. XM_017023880.2XP_016879369.2  protein MTSS 2 isoform X4

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  6. XM_011523453.3XP_011521755.3  protein MTSS 2 isoform X1

    Conserved Domains (2) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam05109
    Location:301654
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  7. XM_011523450.2XP_011521752.1  protein MTSS 2 isoform X7

    Conserved Domains (2) summary
    cd07643
    Location:48264
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam05109
    Location:326679
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  8. XM_011523458.2XP_011521760.1  protein MTSS 2 isoform X8

    Conserved Domains (1) summary
    cl12013
    Location:891
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. XM_017023883.2XP_016879372.2  protein MTSS 2 isoform X10

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  10. XM_017023882.2XP_016879371.2  protein MTSS 2 isoform X9

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
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