Format

Send to:

Choose Destination

MTSS1L MTSS1L, I-BAR domain containing [ Homo sapiens (human) ]

Gene ID: 92154, updated on 5-Aug-2018

Summary

Official Symbol
MTSS1Lprovided by HGNC
Official Full Name
MTSS1L, I-BAR domain containingprovided by HGNC
Primary source
HGNC:HGNC:25094
See related
Ensembl:ENSG00000132613 MIM:616951; Vega:OTTHUMG00000177023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABBA; ABBA1; ABBA-1
Expression
Broad expression in brain (RPKM 49.9), endometrium (RPKM 14.9) and 19 other tissues See more
Orthologs

Genomic context

See MTSS1L in Genome Data Viewer
Location:
16q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (70661204..70686051, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70695107..70719954, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene splicing factor 3b subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene interleukin 34 Neighboring gene Vac14, PIKFYVE complex component Neighboring gene VAC14 antisense RNA 1 Neighboring gene transfer RNA-Gly (GCC) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Rac GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin monomer binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to platelet-derived growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium organization IEA
Inferred from Electronic Annotation
more info
 
plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
ruffle assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MTSS1-like protein
Names
actin-bundling with BAIAP2 homology protein 1
metastasis suppressor 1-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051360.1 RefSeqGene

    Range
    5001..29848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138383.2NP_612392.1  MTSS1-like protein

    See identical proteins and their annotated locations for NP_612392.1

    Status: VALIDATED

    Source sequence(s)
    AB115770, AC020763, BU859607
    Consensus CDS
    CCDS32476.1
    UniProtKB/Swiss-Prot
    Q765P7
    Related
    ENSP00000341171.6, OTTHUMP00000255655, ENST00000338779.10, OTTHUMT00000434927
    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    70661204..70686051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256236.5XP_005256293.3  MTSS1-like protein isoform X6

    Conserved Domains (1) summary
    cd07643
    Location:6236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  2. XM_011523454.3XP_011521756.3  MTSS1-like protein isoform X2

    Conserved Domains (2) summary
    cd07643
    Location:6236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl25496
    Location:298651
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  3. XM_017023881.2XP_016879370.2  MTSS1-like protein isoform X5

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  4. XM_017023879.2XP_016879368.2  MTSS1-like protein isoform X3

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  5. XM_017023880.2XP_016879369.2  MTSS1-like protein isoform X4

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  6. XM_011523453.3XP_011521755.3  MTSS1-like protein isoform X1

    Conserved Domains (2) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl25496
    Location:301654
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  7. XM_011523450.2XP_011521752.1  MTSS1-like protein isoform X7

    Conserved Domains (1) summary
    cd07643
    Location:48264
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  8. XM_011523458.2XP_011521760.1  MTSS1-like protein isoform X8

    Conserved Domains (1) summary
    cl12013
    Location:891
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. XM_017023883.2XP_016879372.2  MTSS1-like protein isoform X10

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
  10. XM_017023882.2XP_016879371.2  MTSS1-like protein isoform X9

    Conserved Domains (1) summary
    cd07643
    Location:6239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
Support Center