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FCMR Fc fragment of IgM receptor [ Homo sapiens (human) ]

Gene ID: 9214, updated on 2-Aug-2021

Summary

Official Symbol
FCMRprovided by HGNC
Official Full Name
Fc fragment of IgM receptorprovided by HGNC
Primary source
HGNC:HGNC:14315
See related
Ensembl:ENSG00000162894 MIM:606015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOSO; FAIM3
Summary
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Expression
Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues See more
Orthologs
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Genomic context

See FCMR in Genome Data Viewer
Location:
1q32.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206903282..206922001, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207076662..207095286, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 20 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 24 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene polymeric immunoglobulin receptor Neighboring gene Fc fragment of IgA and IgM receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fas apoptotic inhibitory molecule 3
Names
Fc mu receptor
IgM Fc fragment receptor
IgM Fc receptor
immunoglobulin mu Fc receptor
regulator of Fas-induced apoptosis Toso

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142473.2NP_001135945.1  fas apoptotic inhibitory molecule 3 isoform b

    See identical proteins and their annotated locations for NP_001135945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AA769146, AI524407, BC006401, BP305798, BP338035, CB158779, DA971987
    Consensus CDS
    CCDS44304.1
    UniProtKB/Swiss-Prot
    O60667
    Related
    ENSP00000404136.2, ENST00000442471.4
  2. NM_001193338.2NP_001180267.1  fas apoptotic inhibitory molecule 3 isoform c precursor

    See identical proteins and their annotated locations for NP_001180267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC098935, AI524407, BC006401, HM480394
    Consensus CDS
    CCDS53467.1
    UniProtKB/Swiss-Prot
    O60667
    Related
    ENSP00000485739.1, ENST00000628511.2
    Conserved Domains (2) summary
    cd05716
    Location:24121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25122
    IG_like; Immunoglobulin like
  3. NM_005449.5NP_005440.1  fas apoptotic inhibitory molecule 3 isoform a precursor

    See identical proteins and their annotated locations for NP_005440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA769146, AI524407, BC006401, BP338035, CB158779
    Consensus CDS
    CCDS1473.1
    UniProtKB/Swiss-Prot
    O60667
    Related
    ENSP00000356058.3, ENST00000367091.8
    Conserved Domains (2) summary
    cd05716
    Location:24121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25122
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    206903282..206922001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273351.4XP_005273408.1  fas apoptotic inhibitory molecule 3 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:24121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:25122
    IG_like; Immunoglobulin like
  2. XM_005273352.5XP_005273409.1  fas apoptotic inhibitory molecule 3 isoform X2

RNA

  1. XR_921999.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001142472.1: Suppressed sequence

    Description
    NM_001142472.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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