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INTS4 integrator complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 92105, updated on 7-Jun-2020

Summary

Official Symbol
INTS4provided by HGNC
Official Full Name
integrator complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:25048
See related
Ensembl:ENSG00000149262 MIM:611348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT4; MST093
Summary
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.0), appendix (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See INTS4 in Genome Data Viewer
Location:
11q14.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (77874418..77994670, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77589766..77705771, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene thyroid hormone responsive

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16733

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 4
Names
MSTP093

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033547.4NP_291025.3  integrator complex subunit 4

    See identical proteins and their annotated locations for NP_291025.3

    Status: VALIDATED

    Source sequence(s)
    BC009859, BC009995, BC015664
    Consensus CDS
    CCDS31644.1
    UniProtKB/Swiss-Prot
    Q96HW7
    Related
    ENSP00000434466.1, ENST00000534064.6
    Conserved Domains (3) summary
    sd00044
    Location:199221
    HEAT; HEAT repeat [structural motif]
    cl26104
    Location:51256
    HEAT_2; HEAT repeats
    cl26317
    Location:379460
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    77874418..77994670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018560.2XP_016874049.1  integrator complex subunit 4 isoform X1

  2. XM_011545352.2XP_011543654.1  integrator complex subunit 4 isoform X2

    Conserved Domains (2) summary
    pfam12755
    Location:88145
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:89111
    HEAT; HEAT repeat [structural motif]
  3. XM_011545353.3XP_011543655.1  integrator complex subunit 4 isoform X3

    Related
    ENSP00000433644.1, ENST00000529807.5
    Conserved Domains (3) summary
    COG1413
    Location:51256
    HEAT; HEAT repeat [General function prediction only]
    pfam12755
    Location:198255
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:199221
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_002957208.1 RNA Sequence

  2. XR_001748037.2 RNA Sequence

  3. XR_001748036.2 RNA Sequence

  4. XR_001748040.2 RNA Sequence

  5. XR_001748039.2 RNA Sequence

    Related
    ENST00000433818.6
  6. XR_002957209.1 RNA Sequence

  7. XR_001748041.2 RNA Sequence

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