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HACD1 3-hydroxyacyl-CoA dehydratase 1 [ Homo sapiens (human) ]

Gene ID: 9200, updated on 7-Oct-2018

Summary

Official Symbol
HACD1provided by HGNC
Official Full Name
3-hydroxyacyl-CoA dehydratase 1provided by HGNC
Primary source
HGNC:HGNC:9639
See related
Ensembl:ENSG00000165996 MIM:610467; Vega:OTTHUMG00000017750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP; PTPLA
Summary
The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 20.1), prostate (RPKM 5.4) and 14 other tissues See more
Orthologs

Genomic context

See HACD1 in Genome Data Viewer
Location:
10p12.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (17589959..17617374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17631031..17659383, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376437 Neighboring gene PRP38 domain containing A pseudogene 2 Neighboring gene STAM antisense RNA 1 (head to head) Neighboring gene signal transducing adaptor molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxy-arachidoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-behenoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-lignoceroyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3R-hydroxyacyl-CoA dehydratase activity EXP
Inferred from Experiment
more info
PubMed 
very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
Names
cementum attachment protein
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
NP_055056.3
XP_005252698.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041789.1 RefSeqGene

    Range
    5001..32416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014241.3NP_055056.3  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1

    See identical proteins and their annotated locations for NP_055056.3

    Status: REVIEWED

    Source sequence(s)
    AW022173, AY455942, BC010353
    Consensus CDS
    CCDS7121.1
    UniProtKB/Swiss-Prot
    B0YJ81
    Related
    ENSP00000355308.3, OTTHUMP00000019240, ENST00000361271.7, OTTHUMT00000047046
    Conserved Domains (1) summary
    pfam04387
    Location:119278
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    17589959..17617374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252641.4XP_005252698.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X1

    Conserved Domains (1) summary
    pfam04387
    Location:125242
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RNA

  1. XR_428651.3 RNA Sequence

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