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TPGS1 tubulin polyglutamylase complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 91978, updated on 8-Mar-2025

Summary

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Official Symbol
TPGS1provided by HGNC
Official Full Name
tubulin polyglutamylase complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:25058
See related
Ensembl:ENSG00000141933 MIM:620709; AllianceGenome:HGNC:25058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGs1; C19orf20; GTRGEO22
Summary
Predicted to enable microtubule binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including adult behavior; chemical synaptic transmission; and protein polyglutamylation. Located in centrosome. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Broad expression in kidney (RPKM 5.9), fat (RPKM 4.3) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See TPGS1 in Genome Data Viewer
Location:
19p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (507497..519654)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (460069..472226)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (507497..519654)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CIMAP1 family member D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9600 Neighboring gene uncharacterized LOC124904608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:489477-489978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9602 Neighboring gene MADCAM1 antisense RNA 1 Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:506573-507430 Neighboring gene Sharpr-MPRA regulatory region 4509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:511078-511918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:511919-512760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:518458-519364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:531801-532457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534117-534693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534694-535269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13563 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:535719-535880 Neighboring gene cell division cycle 34, ubiquitin conjugating enzyme Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:543421-544066 Neighboring gene granzyme M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase. Regnard C, et al. J Cell Sci, 2003 Oct 15. PMID 12972506
  2. Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer. Liao L, et al. Cancer Res, 2023 Feb 3. PMID 36484700, Free PMC Article
  3. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Dehal P, et al. Science, 2001 Jul 6. PMID 11441184
  4. The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. O'Loughlin T, et al. EMBO Rep, 2018 Apr. PMID 29467281, Free PMC Article
  5. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isolation and functional characterization of the mouse PGs1 ortholog, and comparison to the human protein.
    Title: Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle localization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase complex subunit 1
Names
gene trap ROSA b-geo 22
polyglutamylase subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033513.3 → NP_277048.2  tubulin polyglutamylase complex subunit 1

    See identical proteins and their annotated locations for NP_277048.2

    Status: VALIDATED

    Source sequence(s)
    BC009520, BM846833
    Consensus CDS
    CCDS42454.1
    UniProtKB/Swiss-Prot
    Q6ZTW0, Q96GE2
    Related
    ENSP00000352265.4, ENST00000359315.6
    Conserved Domains (1) summary
    cl02594
    Location:36 → 74
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    507497..519654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    460069..472226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZTW0.2 GenPept UniProtKB/Swiss-Prot:Q6ZTW0

Gene LinkOut

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