Format

Send to:

Choose Destination

MYOZ3 myozenin 3 [ Homo sapiens (human) ]

Gene ID: 91977, updated on 1-Aug-2020

Summary

Official Symbol
MYOZ3provided by HGNC
Official Full Name
myozenin 3provided by HGNC
Primary source
HGNC:HGNC:18565
See related
Ensembl:ENSG00000164591 MIM:610735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CS3; CS-3; FRP3; FATZ-3
Summary
The protein encoded by this gene is specifically expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]
Expression
Biased expression in prostate (RPKM 4.0), testis (RPKM 2.8) and 10 other tissues See more
Orthologs

Genomic context

See MYOZ3 in Genome Data Viewer
Location:
5q33.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150660841..150679368)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150040403..150058930)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene N-deacetylase and N-sulfotransferase 1 Neighboring gene Sharpr-MPRA regulatory region 2793 Neighboring gene synaptopodin Neighboring gene RNA binding motif protein 22 Neighboring gene dynactin subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FATZ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telethonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myozenin-3
Names
FATZ-related protein 3
calsarcin-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032584.1 RefSeqGene

    Range
    5411..23528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001122853.3NP_001116325.1  myozenin-3

    See identical proteins and their annotated locations for NP_001116325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA969304, AJ300586, BP360917, DB054183
    Consensus CDS
    CCDS4309.1
    UniProtKB/Swiss-Prot
    Q8TDC0
    Related
    ENSP00000428815.1, ENST00000517768.5
    Conserved Domains (1) summary
    pfam05556
    Location:1251
    Calsarcin; Calcineurin-binding protein (Calsarcin)
  2. NM_133371.4NP_588612.2  myozenin-3

    See identical proteins and their annotated locations for NP_588612.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA969304, AJ300586, BP360917, DB069077
    Consensus CDS
    CCDS4309.1
    UniProtKB/Swiss-Prot
    Q8TDC0
    Related
    ENSP00000297130.4, ENST00000297130.4
    Conserved Domains (1) summary
    pfam05556
    Location:1251
    Calsarcin; Calcineurin-binding protein (Calsarcin)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    150660841..150679368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center