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ZNF300 zinc finger protein 300 [ Homo sapiens (human) ]

Gene ID: 91975, updated on 3-May-2025
Official Symbol
ZNF300provided by HGNC
Official Full Name
zinc finger protein 300provided by HGNC
Primary source
HGNC:HGNC:13091
See related
Ensembl:ENSG00000145908 MIM:612429; AllianceGenome:HGNC:13091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in ovary (RPKM 3.4), testis (RPKM 3.0) and 24 other tissues See more
Orthologs
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See ZNF300 in Genome Data Viewer
Location:
5q33.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150894399..150904980, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151430897..151441478, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150273961..150284542, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene immunity related GTPase M Neighboring gene uncharacterized LOC124901113 Neighboring gene uncharacterized LOC124901111 Neighboring gene uncharacterized LOC124901112 Neighboring gene zinc finger protein 300 pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • DKFZp686B24204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 300
Names
kruppel-like zinc finger protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016866.1 RefSeqGene

    Range
    5004..15585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172831.3NP_001166302.1  zinc finger protein 300 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010441
    Consensus CDS
    CCDS54940.1
    UniProtKB/Swiss-Prot
    Q96RE9
    Conserved Domains (6) summary
    smart00349
    Location:2484
    KRAB; krueppel associated box
    COG5048
    Location:258616
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:483503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:481503
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2463
    KRAB; KRAB box
    pfam13465
    Location:327352
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001172832.3NP_001166303.1  zinc finger protein 300 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC010441
    Consensus CDS
    CCDS54939.1
    UniProtKB/Swiss-Prot
    Q96RE9
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:206564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:431451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:275300
    zf-H2C2_2; Zinc-finger double domain
  3. NM_052860.4NP_443092.1  zinc finger protein 300 isoform 2

    See identical proteins and their annotated locations for NP_443092.1

    Status: REVIEWED

    Source sequence(s)
    AC010441
    Consensus CDS
    CCDS4311.2
    UniProtKB/Swiss-Prot
    A8MY91, B3KU35, B4DU78, F5GWS1, Q06DQ3, Q17RP3, Q5H9N5, Q96RE9
    Related
    ENSP00000274599.5, ENST00000274599.10
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:294590
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467487
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    150894399..150904980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417874.1XP_047273830.1  zinc finger protein 300 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    151430897..151441478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353792.1XP_054209767.1  zinc finger protein 300 isoform X1