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EOLA1 endothelium and lymphocyte associated ASCH domain 1 [ Homo sapiens (human) ]

Gene ID: 91966, updated on 3-Apr-2024

Summary

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Official Symbol
EOLA1provided by HGNC
Official Full Name
endothelium and lymphocyte associated ASCH domain 1provided by HGNC
Primary source
HGNC:HGNC:28089
See related
Ensembl:ENSG00000197620 MIM:300954; AllianceGenome:HGNC:28089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf40; CXorf40A
Summary
Involved in regulation of interleukin-6 production. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 8.2), bone marrow (RPKM 2.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149540601..149555345)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (147806368..147821110)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148622146..148636889)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene IDSP1 recombination region Neighboring gene EOLA1 divergent transcript Neighboring gene iduronate 2-sulfatase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21043 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:148621960-148622150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30016 Neighboring gene heat shock transcription factor family, X-linked member 3 Neighboring gene MAGE family member A9B Neighboring gene heat shock transcription factor family, X-linked 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal Structure of Human EOLA1 Implies Its Possibility of RNA Binding. Kim M, et al. Molecules, 2019 Sep 29. PMID 31569543, Free PMC Article
  2. The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer. Wu M, et al. Mediators Inflamm, 2019. PMID 31007603, Free PMC Article
  3. EOLA1 protects lipopolysaccharide induced IL-6 production and apoptosis by regulation of MT2A in human umbilical vein endothelial cells. Liu Y, et al. Mol Cell Biochem, 2014 Oct. PMID 24916366, Free PMC Article
  4. [Subcellular localization of human endothelial-overexpressed lipopolysaccharide-associated factor 1 protein]. Luo M, et al. Zhonghua Shao Shang Za Zhi, 2010 Dec. PMID 21223654
  5. [The effect of inhibiting EOLA1 expression in ECV304 cells]. Liang ZW, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2007 Jun. PMID 17557240

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results of immunofluorescence and immunohistochemistry showed that EOLA1 was expressed in the epithelial tissues of Diabetic Foot Ulcer.
    Title: The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer.
  2. Data shows that EOLA1 in HUVEC dramatically decreased inflammation factor IL-6 production and apoptosis induced by LPS treatment.
    Title: EOLA1 protects lipopolysaccharide induced IL-6 production and apoptosis by regulation of MT2A in human umbilical vein endothelial cells.
  3. EOLA1 protein is localized in the nucleus and the matrix of ECV304 cells, and it plays a role as a signal transduction factor.
    Title: [Subcellular localization of human endothelial-overexpressed lipopolysaccharide-associated factor 1 protein].
  4. effect of inhibiting the expression of endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1) on proliferation of human umbilical vein endothelial cell line ECV304
    Title: [The effect of inhibiting EOLA1 expression in ECV304 cells].
  5. Findings suggest that EOLA1 is a novel gene and the interaction of EOLA1 and MT2A may play an important role in cell protection in inflammation reaction.
    Title: [Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation].
  6. EOLA1 and MT2A may have an important role of cell protection in inflammation reaction.
    Title: Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16423, FLJ52212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein EOLA1
Names
endothelial-overexpressed lipopolysaccharide-associated factor 1
protein CXorf40A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171907.3 → NP_001165378.1  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_001165378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AI088770, AW952651, BC104930, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000421745.1, ENST00000393985.8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  2. NM_001171908.3 → NP_001165379.1  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_001165379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AI088770, AW952651, BC143662, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000425520.1, ENST00000423540.6
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  3. NM_001171909.4 → NP_001165380.1  protein EOLA1 isoform b

    See identical proteins and their annotated locations for NP_001165380.1

    Status: VALIDATED

    Source sequence(s)
    AC244197, AK300334, BC065539, CR984770
    Consensus CDS
    CCDS55522.1
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000422312.1, ENST00000422892.2
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  4. NM_001324274.2 → NP_001311203.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197, BG105508, DC339764
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000427540.1, ENST00000450602.6
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  5. NM_001324275.2 → NP_001311204.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197, BG105508, BI819316
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  6. NM_001324276.2 → NP_001311205.1  protein EOLA1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS55522.1
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000423160.1, ENST00000434353.6
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  7. NM_001324277.2 → NP_001311206.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000423099.1, ENST00000441248.5
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  8. NM_001324278.2 → NP_001311207.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  9. NM_001324279.2 → NP_001311208.1  protein EOLA1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS55522.1
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000423708.1, ENST00000514208.5
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  10. NM_001324280.2 → NP_001311209.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

  11. NM_178124.6 → NP_835225.2  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_835225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI088770, AW952651, BC065539, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    A0A0A0MTB5, A8K784, B7Z6H6, B7ZL96, D6RA72, E7ENU3, Q2M3E9, Q8TE69
    UniProtKB/TrEMBL
    S4R3G8
    Related
    ENSP00000422512.1, ENST00000423421.5
    Conserved Domains (1) summary
    smart01022
    Location:6 → 114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    149540601..149555345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442629.1 → XP_047298585.1  protein EOLA1 isoform X1

  2. XM_047442630.1 → XP_047298586.1  protein EOLA1 isoform X2

  3. XM_005262349.5 → XP_005262406.3  protein EOLA1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    147806368..147821110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328105.1 → XP_054184080.1  protein EOLA1 isoform X1

  2. XM_054328106.1 → XP_054184081.1  protein EOLA1 isoform X2

  3. XM_054328107.1 → XP_054184082.1  protein EOLA1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TE69.3 GenPept UniProtKB/Swiss-Prot:Q8TE69

Gene LinkOut

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