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KCNAB3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 [ Homo sapiens (human) ]

Gene ID: 9196, updated on 12-Oct-2019

Summary

Official Symbol
KCNAB3provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily A regulatory beta subunit 3provided by HGNC
Primary source
HGNC:HGNC:6230
See related
Ensembl:ENSG00000170049 MIM:604111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AKR6A9; KCNA3B; KCNA3.1B; KV-BETA-3
Summary
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]
Expression
Broad expression in endometrium (RPKM 5.0), brain (RPKM 1.9) and 18 other tissues See more
Orthologs

Genomic context

See KCNAB3 in Genome Data Viewer
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7921859..7930346, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7825177..7833180, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ring finger protein 227 Neighboring gene trafficking protein particle complex 1 Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene uncharacterized LOC105371517

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99419, MGC116886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
voltage-gated potassium channel subunit beta-3
Names
K(+) channel subunit beta-3
potassium channel, voltage gated subfamily A regulatory beta subunit 3
potassium channel, voltage-dependent, beta-3 subunit
potassium voltage-gated channel, shaker-related subfamily, beta member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004732.3NP_004723.2  voltage-gated potassium channel subunit beta-3

    See identical proteins and their annotated locations for NP_004723.2

    Status: REVIEWED

    Source sequence(s)
    AA716741, AI090408, BC096232, BQ277958, CF455307
    Consensus CDS
    CCDS11124.1
    UniProtKB/Swiss-Prot
    O43448
    Related
    ENSP00000302719.2, ENST00000303790.2
    Conserved Domains (1) summary
    TIGR01293
    Location:80396
    Kv_beta; voltage-dependent potassium channel beta subunit, animal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7921859..7930346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025305.1XP_016880794.1  voltage-gated potassium channel subunit beta-3 isoform X3

  2. XM_017025306.1XP_016880795.1  voltage-gated potassium channel subunit beta-3 isoform X4

  3. XM_011524068.1XP_011522370.1  voltage-gated potassium channel subunit beta-3 isoform X1

    Conserved Domains (1) summary
    cd06660
    Location:31300
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
  4. XM_017025304.1XP_016880793.1  voltage-gated potassium channel subunit beta-3 isoform X2

  5. XM_024451026.1XP_024306794.1  voltage-gated potassium channel subunit beta-3 isoform X5

    Conserved Domains (1) summary
    cl00470
    Location:65352
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

RNA

  1. XR_001752679.1 RNA Sequence

  2. XR_001752678.1 RNA Sequence

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