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SLC16A7 solute carrier family 16 member 7 [ Homo sapiens (human) ]

Gene ID: 9194, updated on 4-Oct-2020

Summary

Official Symbol
SLC16A7provided by HGNC
Official Full Name
solute carrier family 16 member 7provided by HGNC
Primary source
HGNC:HGNC:10928
See related
Ensembl:ENSG00000118596 MIM:603654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT2
Summary
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues See more
Orthologs

Genomic context

See SLC16A7 in Genome Data Viewer
Location:
12q14.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (59595934..59789841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (59989821..60183636)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2448 Neighboring gene RNA, U4 small nuclear 20, pseudogene Neighboring gene polyadenylate-binding protein 4 pseudogene Neighboring gene ubiquitin-like protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lactate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyruvate secondary active transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
pyruvate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
lactate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyruvate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
monocarboxylate transporter 2
Names
solute carrier family 16 (monocarboxylate transporter), member 7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270622.2NP_001257551.1  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_001257551.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AC119793, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    UniProtKB/TrEMBL
    A0A024RBB2
    Related
    ENSP00000449547.1, ENST00000552432.5
    Conserved Domains (1) summary
    TIGR00892
    Location:15458
    2A0113; monocarboxylate transporter 1
  2. NM_001270623.2NP_001257552.1  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_001257552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AC119793, AF049608, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    UniProtKB/TrEMBL
    A0A024RBB2
    Related
    ENSP00000448071.1, ENST00000547379.6
    Conserved Domains (1) summary
    TIGR00892
    Location:15458
    2A0113; monocarboxylate transporter 1
  3. NM_004731.5NP_004722.2  monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_004722.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AF058056, BC030693
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    UniProtKB/TrEMBL
    A0A024RBB2
    Related
    ENSP00000261187.4, ENST00000261187.8
    Conserved Domains (1) summary
    TIGR00892
    Location:15458
    2A0113; monocarboxylate transporter 1

RNA

  1. NR_073055.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK301725, BC030693
  2. NR_073056.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK310281, BC030693

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    59595934..59789841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538989.2XP_011537291.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537291.1

    Conserved Domains (2) summary
    cd06174
    Location:20449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15484
    2A0113; monocarboxylate transporter 1
  2. XM_011538992.2XP_011537294.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537294.1

    Conserved Domains (2) summary
    cd06174
    Location:20449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15484
    2A0113; monocarboxylate transporter 1
  3. XM_024449276.1XP_024305044.1  monocarboxylate transporter 2 isoform X2

    Conserved Domains (1) summary
    TIGR00892
    Location:15458
    2A0113; monocarboxylate transporter 1
  4. XM_011538991.2XP_011537293.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537293.1

    Conserved Domains (2) summary
    cd06174
    Location:20449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15484
    2A0113; monocarboxylate transporter 1
  5. XM_005269231.4XP_005269288.1  monocarboxylate transporter 2 isoform X2

    See identical proteins and their annotated locations for XP_005269288.1

    UniProtKB/Swiss-Prot
    O60669
    UniProtKB/TrEMBL
    A0A024RBB2
    Related
    ENSP00000446722.1, ENST00000548610.5
    Conserved Domains (1) summary
    TIGR00892
    Location:15458
    2A0113; monocarboxylate transporter 1
  6. XM_011538990.3XP_011537292.1  monocarboxylate transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011537292.1

    Conserved Domains (2) summary
    cd06174
    Location:20449
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15484
    2A0113; monocarboxylate transporter 1
  7. XM_011538993.3XP_011537295.1  monocarboxylate transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_011537295.1

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  8. XM_017020224.1XP_016875713.1  monocarboxylate transporter 2 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  9. XM_017020225.1XP_016875714.1  monocarboxylate transporter 2 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  10. XM_017020227.1XP_016875716.1  monocarboxylate transporter 2 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  11. XM_017020226.2XP_016875715.1  monocarboxylate transporter 2 isoform X3

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  12. XM_011538995.2XP_011537297.1  monocarboxylate transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_011537297.1

    Conserved Domains (1) summary
    cd06174
    Location:1324
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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