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TIMD4 T cell immunoglobulin and mucin domain containing 4 [ Homo sapiens (human) ]

Gene ID: 91937, updated on 23-Nov-2021

Summary

Official Symbol
TIMD4provided by HGNC
Official Full Name
T cell immunoglobulin and mucin domain containing 4provided by HGNC
Primary source
HGNC:HGNC:25132
See related
Ensembl:ENSG00000145850 MIM:610096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM4; SMUCKLER
Expression
Biased expression in lymph node (RPKM 8.4), testis (RPKM 2.6) and 5 other tissues See more
Orthologs
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Genomic context

See TIMD4 in Genome Data Viewer
Location:
5q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (156919292..156963226, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156346303..156390237, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 556, pseudogene Neighboring gene PPP1R2 family member B Neighboring gene apolipoprotein O pseudogene 1 Neighboring gene hepatitis A virus cellular receptor 1 Neighboring gene hepatitis A virus cellular receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Common variants at 30 loci contribute to polygenic dyslipidemia.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag TIM-4 inhibits the release of HIV-1 in terms of reduced levels of CA and RT activity in virus particles, and induces the accumulation of cell-associated CA PubMed
reverse transcriptase gag-pol TIM-4 inhibits the release of HIV-1 in terms of reduced levels of CA and RT activity in virus particles, and induces the accumulation of cell-associated CA PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27515

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-cell immunoglobulin and mucin domain-containing protein 4
Names
T-cell immunoglobulin mucin receptor 4
T-cell membrane protein 4
TIM-4
TIMD-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146726.2NP_001140198.1  T-cell immunoglobulin and mucin domain-containing protein 4 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AA843555, AC008491, AC026777, BC008988
    Consensus CDS
    CCDS54943.1
    UniProtKB/Swiss-Prot
    Q96H15
    Related
    ENSP00000385973.3, ENST00000407087.4
    Conserved Domains (2) summary
    smart00410
    Location:27115
    IG_like; Immunoglobulin like
    pfam07686
    Location:23128
    V-set; Immunoglobulin V-set domain
  2. NM_138379.3NP_612388.2  T-cell immunoglobulin and mucin domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_612388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA843555, AC008491, BC008988
    Consensus CDS
    CCDS4332.1
    UniProtKB/Swiss-Prot
    Q96H15
    Related
    ENSP00000274532.2, ENST00000274532.7
    Conserved Domains (2) summary
    smart00410
    Location:27115
    IG_like; Immunoglobulin like
    pfam07686
    Location:23128
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    156919292..156963226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010021.2XP_016865510.1  T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1

  2. XM_011534694.3XP_011532996.1  T-cell immunoglobulin and mucin domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    pfam07686
    Location:23128
    V-set; Immunoglobulin V-set domain
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