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CALML4 calmodulin like 4 [ Homo sapiens (human) ]

Gene ID: 91860, updated on 23-Nov-2021

Summary

Official Symbol
CALML4provided by HGNC
Official Full Name
calmodulin like 4provided by HGNC
Primary source
HGNC:HGNC:18445
See related
Ensembl:ENSG00000129007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NY-BR-20
Expression
Broad expression in colon (RPKM 15.5), duodenum (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See CALML4 in Genome Data Viewer
Location:
15q23
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68190705..68206110, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68483043..68498448, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene Neighboring gene protein inhibitor of activated STAT 1 Neighboring gene uncharacterized LOC105370871 Neighboring gene Sharpr-MPRA regulatory region 569 Neighboring gene CLN6 transmembrane ER protein Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calmodulin-like protein 4
Names
serologically defined breast cancer antigen NY-BR-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031733.3NP_001026903.3  calmodulin-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC107871
    Consensus CDS
    CCDS42052.1
    Related
    ENSP00000400755.3, ENST00000448060.7
    Conserved Domains (1) summary
    PTZ00184
    Location:796
    PTZ00184; calmodulin; Provisional
  2. NM_001286694.1NP_001273623.1  calmodulin-like protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001273623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC107871, BC009516, BX439220, BX640702, BX640817
    Consensus CDS
    CCDS66808.1
    UniProtKB/Swiss-Prot
    Q96GE6
    Related
    ENSP00000435285.2, ENST00000395463.3
    Conserved Domains (1) summary
    cl25352
    Location:4110
    EFh_PEF; The penta-EF hand (PEF) family
  3. NM_001286695.1NP_001273624.1  calmodulin-like protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001273624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC107871, BX439220, BX640702, BX640817
    UniProtKB/Swiss-Prot
    Q96GE6
    Related
    ENSP00000438177.2, ENST00000540479.6
    Conserved Domains (1) summary
    cl08302
    Location:2072
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_033429.3NP_219501.3  calmodulin-like protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC107871
    Consensus CDS
    CCDS10226.2
    Related
    ENSP00000419081.2, ENST00000467889.3
    Conserved Domains (1) summary
    PTZ00184
    Location:1143
    PTZ00184; calmodulin; Provisional

RNA

  1. NR_104583.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC107871, BX439220, BX640702, BX640817
    Related
    ENST00000395465.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68190705..68206110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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