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ZW10 zw10 kinetochore protein [ Homo sapiens (human) ]

Gene ID: 9183, updated on 7-Jun-2020

Summary

Official Symbol
ZW10provided by HGNC
Official Full Name
zw10 kinetochore proteinprovided by HGNC
Primary source
HGNC:HGNC:13194
See related
Ensembl:ENSG00000086827 MIM:603954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZW10; KNTC1AP
Summary
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See ZW10 in Genome Data Viewer
Location:
11q23.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (113733183..113773699, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113603905..113644485, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 5 Neighboring gene mitochondrial translational release factor 1 like pseudogene 1 Neighboring gene ribosomal protein S29 pseudogene 19 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene claudin 25 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
centromeric DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IGI
Inferred from Genetic Interaction
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Dsl1/NZR complex IDA
Inferred from Direct Assay
more info
PubMed 
RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RZZ complex IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centromere/kinetochore protein zw10 homolog
Names
ZW10 homolog, centromere/kinetochore protein
ZW10, kinetochore associated, homolog
zeste white 10 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004724.4NP_004715.1  centromere/kinetochore protein zw10 homolog

    See identical proteins and their annotated locations for NP_004715.1

    Status: REVIEWED

    Source sequence(s)
    BC128264, BM833775, BQ773926, DB506745, U54996
    Consensus CDS
    CCDS8363.1
    UniProtKB/Swiss-Prot
    O43264
    Related
    ENSP00000200135.3, ENST00000200135.8
    Conserved Domains (2) summary
    pfam06248
    Location:9621
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:598768
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    113733183..113773699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018558.2XP_016874047.1  centromere/kinetochore protein zw10 homolog isoform X1

    Conserved Domains (2) summary
    pfam06248
    Location:9557
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:534704
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017018559.2XP_016874048.1  centromere/kinetochore protein zw10 homolog isoform X2

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