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EXOC3L4 exocyst complex component 3 like 4 [ Homo sapiens (human) ]

Gene ID: 91828, updated on 23-Nov-2021

Summary

Official Symbol
EXOC3L4provided by HGNC
Official Full Name
exocyst complex component 3 like 4provided by HGNC
Primary source
HGNC:HGNC:20120
See related
Ensembl:ENSG00000205436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf73
Expression
Biased expression in duodenum (RPKM 4.9), small intestine (RPKM 2.6) and 10 other tissues See more
Orthologs
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Genomic context

See EXOC3L4 in Genome Data Viewer
Location:
14q32.32
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103094202..103110562)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103566481..103576896)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase beta Neighboring gene ribosomal protein L13 pseudogene 6 Neighboring gene LBH domain containing 2 Neighboring gene long intergenic non-protein coding RNA 677 Neighboring gene TNF alpha induced protein 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
GeneReviews: Not available
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
GeneReviews: Not available
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
exocyst complex component 3-like protein 4
Names
SEC6-like protein C14orf73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077594.2NP_001071062.1  exocyst complex component 3-like protein 4

    See identical proteins and their annotated locations for NP_001071062.1

    Status: VALIDATED

    Source sequence(s)
    AL161669
    Consensus CDS
    CCDS32163.1
    UniProtKB/Swiss-Prot
    Q17RC7
    Related
    ENSP00000369409.3, ENST00000380069.7
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  2. NM_001394941.1NP_001381870.1  exocyst complex component 3-like protein 4

    Status: VALIDATED

    Source sequence(s)
    AL161669
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  3. NM_001394942.1NP_001381871.1  exocyst complex component 3-like protein 4

    Status: VALIDATED

    Source sequence(s)
    AL161669
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103094202..103110562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537333.2XP_011535635.1  exocyst complex component 3-like protein 4 isoform X3

    Conserved Domains (1) summary
    pfam06046
    Location:217746
    Sec6; Exocyst complex component Sec6
  2. XM_011537332.2XP_011535634.1  exocyst complex component 3-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011535634.1

    UniProtKB/Swiss-Prot
    Q17RC7
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  3. XM_011537330.2XP_011535632.1  exocyst complex component 3-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011535632.1

    UniProtKB/Swiss-Prot
    Q17RC7
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  4. XM_011537331.1XP_011535633.1  exocyst complex component 3-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011535633.1

    UniProtKB/Swiss-Prot
    Q17RC7
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  5. XM_011537329.2XP_011535631.1  exocyst complex component 3-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_011535631.1

    UniProtKB/Swiss-Prot
    Q17RC7
    Conserved Domains (1) summary
    pfam06046
    Location:180709
    Sec6; Exocyst complex component Sec6
  6. XM_011537324.2XP_011535626.1  exocyst complex component 3-like protein 4 isoform X2

    Conserved Domains (1) summary
    pfam06046
    Location:238761
    Sec6; Exocyst complex component Sec6
  7. XM_011537323.3XP_011535625.1  exocyst complex component 3-like protein 4 isoform X1

    Conserved Domains (1) summary
    pfam06046
    Location:238767
    Sec6; Exocyst complex component Sec6
  8. XM_011537334.1XP_011535636.1  exocyst complex component 3-like protein 4 isoform X5

    Conserved Domains (1) summary
    pfam06046
    Location:1530
    Sec6; Exocyst complex component Sec6

RNA

  1. XR_943558.2 RNA Sequence

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