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RASSF9 Ras association domain family member 9 [ Homo sapiens (human) ]

Gene ID: 9182, updated on 13-Mar-2020

Summary

Official Symbol
RASSF9provided by HGNC
Official Full Name
Ras association domain family member 9provided by HGNC
Primary source
HGNC:HGNC:15739
See related
Ensembl:ENSG00000198774 MIM:610383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAMCI; PCIP1; P-CIP1
Summary
The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 3.5), esophagus (RPKM 3.2) and 23 other tissues See more
Orthologs

Genomic context

See RASSF9 in Genome Data Viewer
Location:
12q21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (85800703..85836409, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (86198331..86230318, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2820 Neighboring gene p53 and DNA damage-regulated protein 1 pseudogene Neighboring gene TM2 domain containing 3 pseudogene Neighboring gene neurotensin Neighboring gene MGAT4 family member C Neighboring gene uncharacterized LOC105369877

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies RASSF9, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosomal transport NAS
Non-traceable Author Statement
more info
PubMed 
intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network transport vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras association domain-containing protein 9
Names
PAM COOH-terminal interactor protein 1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor protein-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005447.4NP_005438.2  ras association domain-containing protein 9

    See identical proteins and their annotated locations for NP_005438.2

    Status: REVIEWED

    Source sequence(s)
    AC016993, AC137768, AK022089
    Consensus CDS
    CCDS44950.1
    UniProtKB/Swiss-Prot
    O75901
    Related
    ENSP00000354884.3, ENST00000361228.5
    Conserved Domains (1) summary
    smart00314
    Location:23118
    RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    85800703..85836409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538988.2XP_011537290.1  ras association domain-containing protein 9 isoform X1

    Conserved Domains (1) summary
    smart00314
    Location:297
    RA; Ras association (RalGDS/AF-6) domain
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