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NXPE3 neurexophilin and PC-esterase domain family member 3 [ Homo sapiens (human) ]

Gene ID: 91775, updated on 4-Jul-2021

Summary

Official Symbol
NXPE3provided by HGNC
Official Full Name
neurexophilin and PC-esterase domain family member 3provided by HGNC
Primary source
HGNC:HGNC:28238
See related
Ensembl:ENSG00000144815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM55C; MST115; MSTP115
Summary
This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in brain (RPKM 6.4), lymph node (RPKM 5.0) and 24 other tissues See more
Orthologs
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Genomic context

See NXPE3 in Genome Data Viewer
Location:
3q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (101779211..101828231)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101498055..101547075)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PDCL3 pseudogene 4 Neighboring gene centrosomal protein 97 Neighboring gene Sharpr-MPRA regulatory region 11 Neighboring gene Sharpr-MPRA regulatory region 7874 Neighboring gene NFKB inhibitor zeta Neighboring gene long intergenic non-protein coding RNA 2085

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30102, MGC15606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NXPE family member 3
Names
family with sequence similarity 55, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053180.2 RefSeqGene

    Range
    5027..54047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134456.2NP_001127928.1  NXPE family member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001127928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    UniProtKB/Swiss-Prot
    Q969Y0
    Related
    ENSP00000417485.1, ENST00000491511.6
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  2. NM_001348990.2NP_001335919.1  NXPE family member 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  3. NM_001348991.2NP_001335920.1  NXPE family member 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  4. NM_001348992.2NP_001335921.1  NXPE family member 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  5. NM_001348993.2NP_001335922.1  NXPE family member 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  6. NM_001348994.2NP_001335923.1  NXPE family member 3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  7. NM_001348995.2NP_001335924.1  NXPE family member 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  8. NM_001348996.2NP_001335925.1  NXPE family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
    Source sequence(s)
    AC020651, AC084198
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  9. NM_001348997.2NP_001335926.1  NXPE family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
    Source sequence(s)
    AC020651, AC084198
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  10. NM_001348998.2NP_001335927.1  NXPE family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 9-11 encode the same isoform (2).
    Source sequence(s)
    AC020651, AC084198
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin
  11. NM_145037.4NP_659474.1  NXPE family member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_659474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same isoform (1).
    Source sequence(s)
    AC020651, AC084198
    Consensus CDS
    CCDS2945.1
    UniProtKB/Swiss-Prot
    Q969Y0
    Related
    ENSP00000273347.5, ENST00000273347.10
    Conserved Domains (1) summary
    pfam06312
    Location:75284
    Neurexophilin

RNA

  1. NR_145993.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate 5' exon structure and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020651, AC084198

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    101779211..101828231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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