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HTR3B 5-hydroxytryptamine receptor 3B [ Homo sapiens (human) ]

Gene ID: 9177, updated on 8-Jul-2021

Summary

Official Symbol
HTR3Bprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 3Bprovided by HGNC
Primary source
HGNC:HGNC:5298
See related
Ensembl:ENSG00000149305 MIM:604654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT3B
Summary
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HTR3B in Genome Data Viewer
Location:
11q23.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (113898923..113949119)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113775518..113817283)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene Sharpr-MPRA regulatory region 42 Neighboring gene 5-hydroxytryptamine receptor 3A Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC101928875

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serotonin-gated cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serotonin-gated cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of serotonin-activated cation-selective channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 3B
Names
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
5-hydroxytryptamine 3 receptor B subunit
serotonin-gated ion channel subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011483.1 RefSeqGene

    Range
    4930..46695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363563.2NP_001350492.1  5-hydroxytryptamine receptor 3B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP001874
    Consensus CDS
    CCDS86249.1
    Related
    ENSP00000443118.1, ENST00000537778.5
    Conserved Domains (1) summary
    cl27321
    Location:24424
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  2. NM_006028.5NP_006019.1  5-hydroxytryptamine receptor 3B isoform 1 precursor

    See identical proteins and their annotated locations for NP_006019.1

    Status: REVIEWED

    Source sequence(s)
    AP001874
    Consensus CDS
    CCDS8364.1
    UniProtKB/Swiss-Prot
    O95264
    Related
    ENSP00000260191.2, ENST00000260191.7
    Conserved Domains (3) summary
    TIGR00860
    Location:8435
    LIC; Cation transporter family protein
    pfam02931
    Location:33239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:246328
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    113898923..113949119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448767.1XP_024304535.1  5-hydroxytryptamine receptor 3B isoform X3

    Conserved Domains (1) summary
    cl27321
    Location:2337
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  2. XM_017018552.2XP_016874041.1  5-hydroxytryptamine receptor 3B isoform X2

    Conserved Domains (2) summary
    pfam02931
    Location:2170
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:177259
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RNA

  1. XR_001748034.2 RNA Sequence

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