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LIN52 lin-52 DREAM MuvB core complex component [ Homo sapiens (human) ]

Gene ID: 91750, updated on 23-Nov-2021

Summary

Official Symbol
LIN52provided by HGNC
Official Full Name
lin-52 DREAM MuvB core complex componentprovided by HGNC
Primary source
HGNC:HGNC:19856
See related
Ensembl:ENSG00000205659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf46; c14_5549
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LIN52 in Genome Data Viewer
Location:
14q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (74084867..74201493)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74551659..74668196)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene basal body orientation factor 1 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene uncharacterized LOC105370563 Neighboring gene RNY4 pseudogene 21 Neighboring gene RNA, 7SL, cytoplasmic 530, pseudogene Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene uncharacterized LOC105370564 Neighboring gene visual system homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Web-based, participant-driven studies yield novel genetic associations for common traits.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DRM complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein lin-52 homolog
Names
lin-52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024674.3NP_001019845.2  protein lin-52 homolog

    Status: VALIDATED

    Source sequence(s)
    AC006349, AK023979, BC094003
    Consensus CDS
    CCDS32120.1
    Related
    ENSP00000451812.2, ENST00000555028.6
    Conserved Domains (1) summary
    pfam10044
    Location:14107
    LIN52; Retinal tissue protein
  2. NM_001372005.1NP_001358934.1  protein lin-52 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005484
    Conserved Domains (1) summary
    pfam10044
    Location:1494
    LIN52; Retinal tissue protein
  3. NM_001372006.1NP_001358935.1  protein lin-52 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005484, AC006349
    Conserved Domains (1) summary
    pfam10044
    Location:12105
    LIN52; Retinal tissue protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    74084867..74201493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537321.3XP_011535623.1  protein lin-52 homolog isoform X3

    Conserved Domains (1) summary
    pfam10044
    Location:50130
    LIN52; Retinal tissue protein
  2. XM_011537322.2XP_011535624.2  protein lin-52 homolog isoform X4

  3. XM_017021764.1XP_016877253.1  protein lin-52 homolog isoform X5

    Conserved Domains (1) summary
    pfam10044
    Location:1898
    LIN52; Retinal tissue protein
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