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MAP3K13 mitogen-activated protein kinase kinase kinase 13 [ Homo sapiens (human) ]

Gene ID: 9175, updated on 25-Nov-2021

Summary

Official Symbol
MAP3K13provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by HGNC
Primary source
HGNC:HGNC:6852
See related
Ensembl:ENSG00000073803 MIM:604915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZK; MLK; MEKK13
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See MAP3K13 in Genome Data Viewer
Location:
3q27.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (185282938..185489094)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185000749..185206882)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 2 Neighboring gene microRNA 5588 Neighboring gene ribosomal protein L4 pseudogene 4 Neighboring gene uncharacterized LOC101929018 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene lipase H

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables IkappaB kinase complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of branching morphogenesis of a nerve ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection arborization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 13
Names
leucine zipper-bearing kinase
mixed lineage kinase
NP_001229243.1
NP_001229246.1
NP_004712.1
XP_011511612.1
XP_016862945.1
XP_016862946.1
XP_016862947.1
XP_016862948.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242314.2NP_001229243.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_001229243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC099661, AK312714, BQ432918
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000399910.1, ENST00000424227.5
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. NM_001242317.2NP_001229246.1  mitogen-activated protein kinase kinase kinase 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC099661, AK297646
    Consensus CDS
    CCDS56298.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000411483.1, ENST00000446828.5
    Conserved Domains (1) summary
    cl21453
    Location:13203
    PKc_like; Protein Kinases, catalytic domain
  3. NM_004721.5NP_004712.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_004712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB001872, AC099661, AC132516
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000265026.3, ENST00000265026.8
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RNA

  1. NR_038322.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks eleven exons and contains an alternate 3' exon, compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 3.
    Source sequence(s)
    AI690808, BC015996, BC036593, BQ432918
    Related
    ENST00000448876.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    185282938..185489094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007456.1XP_016862945.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    UniProtKB/Swiss-Prot
    O43283
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. XM_017007458.1XP_016862947.1  mitogen-activated protein kinase kinase kinase 13 isoform X3

  3. XM_011513310.2XP_011511612.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

    See identical proteins and their annotated locations for XP_011511612.1

    UniProtKB/Swiss-Prot
    O43283
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  4. XM_017007457.1XP_016862946.1  mitogen-activated protein kinase kinase kinase 13 isoform X2

    Related
    ENSP00000409325.1, ENST00000443863.5
  5. XM_017007459.2XP_016862948.1  mitogen-activated protein kinase kinase kinase 13 isoform X3

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